摘要
目的考察介质的pH对甘草次酸经皮渗透性的影响。方法采用HPLC法测定甘草次酸在不同pH介质中的饱和溶解度,采用摇瓶法测定其在不同pH正辛醇/PBS缓冲液中的表观油水分配系数,采用体外Franz扩散池法考察不同pH的甘草次酸饱和溶液在离体小鼠皮上的经皮渗透性。结果 pH5.0～10.8时,甘草次酸饱和溶液的稳态透皮速率随pH升高而增大,而表观渗透系数随pH升高而减小。结论甘草次酸在介质中饱和时,可通过调节pH来改善甘草次酸的稳态透皮速率。
OBJECTIVE To study the effect of pH on penetration of glycyrrhetinic acid through skin.METHODS The apparent solubilities of glycyrrhetinic acid in media with different pH values were determined.The apparent distribution coefficients of glycyrrhetinic acid were determined using shake-flask method.The penetration parameteres of glycyrrhetinic acid through rat skin in vitro were measured using Franz diffusion cell.RESULTS With increase of pH within 5.0-10.8,the steady state flux of glycyrrhetinic acid was increased,but the apparent permeability coefficient was decreased.CONCLUSION At saturation status,changing the pH may modify the penetration rate of glycyrrhetinic acid.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2012年第2期162-165,共4页
West China Journal of Pharmaceutical Sciences
基金
国家十一五科技支撑计划(2008BA153B071)
江西中医学院创新人才实验区招标课题(JZ0908)
关键词
PH
甘草次酸
经皮渗透性
pH
Glycyrrhetinic acid
Percutaneous absorption
