摘要
甘草次酸属于五环三萜类化合物,是多种天然产物的功能性成分,在自然界中分布广泛,并显示出多种生物活性,如：保肝、抗癌、抗炎、抗菌、抗病毒等多种药理作用,并具有良好的抗癌活性,且本身毒性较低。甘草次酸已被应用于临床,药用开发前景广阔。因此,本文以甘草次酸为先导化合物,在其C-3位进行了结构修饰,偶联了氨基酸以提高其水溶性,共合成了3种新的中间体和3种新的目标产物,并利用IR和~1H NMR波谱技术对其结构进行了表征。
Glycyrrhetinic acid belongs to pentacyclic triterpenoid compounds.It＇s the functional ingredients of many natural products.The glycyrrhetinic acid is widely distributed in nature,and shows a variety of biological activities,such as：liver,anti-cancer anti-inflammatory,antibacterial,antiviral and other pharmacological effects,and with good antitumor activity.Its toxicity is low.Glycyrrhetinic acid has been used in clinical and has a large pharmaceutical development prospect.Therefore,we used glycyrrhetinic acid as a leading compound and had the structural modification on C-3,coupling of amino acids to improve its water-soluble. We synthesis three of intermediates and three final products and IR and ~1H NMR spectroscopy techniques were used to characterize their structure.
出处
《大连大学学报》
2011年第3期40-43,71,共5页
Journal of Dalian University
关键词
甘草次酸
衍生物
合成
glycyrrhetinic acid
derivatives
synthesis
