摘要
目的评价Th1细胞对NOD小鼠糖尿病早期变化的作用。方法选择4 w、8 w和16 w的雌性NOD小鼠,采用流式细胞术测定脾Th1细胞,采用免疫组化法检测胰腺内Th1细胞。结果随年龄增加,雌性NOD小鼠脾和胰腺内Th1细胞逐渐增加。结论 Th1细胞参与NOD小鼠糖尿病早期的病理过程。
Objective To observe the effect of Thl cells in the early stage of non-obese diabetic （NOD） mice and evaluate their contributions to the onset of diabetes. Methods Female NOD mice of 4, 8 and 16 weeks were chosen. Thl cells were detected in spleen by flow cytometer. Then the distribudo^of Thl cells was analyzed in pancreas by IHC. Results Thl cells frequency was increased gradually from 4 to 16 weeks in both spleen and pancreas. Conclusions Thl cells may be take part in the onset of diabetes in the early stage of NOD
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2012年第7期1411-1412,共2页
Chinese Journal of Gerontology
基金
吉林省教育厅“十一五”科学技术研究项目(No.2008401)
