摘要
目的探讨艾滋病(AIDS)合并播散性马尔尼菲青霉菌病(DPSM)的特征性临床表现。方法回顾性分析449例经病原学确诊的AIDS合并DPSM常见的15项临床表现,并与非DPSM的AIDS456例相比较,筛选出一组典型临床表现。结果确诊DPSM组发热、畏寒、腹痛、脐窝样皮疹、浅表淋巴结肿大、肝肿大、脾肿大、腹主动脉旁/腹腔淋巴结肿大、白细胞减少、血小板减少、ALT升高、AST升高12个表现出现率高于非DPSM组,差异有统计学意义;其中发热、脐窝样皮疹、腹主动脉旁/腹腔淋巴结肿大、血小板减少、AST升高5个临床表现以组合形式出现情况,DPSM组5个同时出现为17.4%、4个同时出现为60.6%、3个同时出现为87.8%,而非DPSM组分别为0、1.1%、8.6%。结论发热、脐窝样皮疹、腹主动脉旁/腹腔淋巴结肿大、血小板减少、AST升高是AIDS合并DPSM患者特征性的一组临床表现。
Objective To discuss the feature of clinical manifestations of acquired immunodeficiency syndrome（AIDS） with disseminated penicilliosis marneffei （DPSM）. Methods Retrospectively analyzed the 15 clinical manifestations of 449 cases of AIDS with DPSM confirmed by etiological examination. Compared them with 456 cases of AIDS without DPSM, and screened a group of typical manifestations. Results The DPSM group had a higher rate than that without DPSM in showing fever, chill, bellyache, hilar-depression-like eruption, enlargement of superficial lymph nodes, hepatomegaly, splenomegaly, enlargement of aortic/abdominal cavity lymph nodes, thrombopenia, raised ALT and AST. It was of statistical significantly. Fever, hilar-depression-like eruption, enlargement of aortic/abdominal cavity lymph nodes, thrombopenia and raised AST showed in relatively group as follows ： For the DPSM group, 17.4% showed 5 manifestations ,60. 6% showed 4 and 87. 8% showed 3 ;while for the group without DPSM, it respectively showed 0, 1.1% and 8.6%. Conclusions Fever, hilar-depression-like eruption, enlargement of aortic/abdominal cavity lymph nodes, thrombopenia and raised AST were a featured group of clinical manifestations for AIDS with DPSM.
出处
《中华临床医师杂志（电子版）》
CAS
2012年第8期24-27,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
南宁市科学研究与技术开发计划项目(200901014C)
关键词
获得性免疫缺陷综合征
马尔尼菲青霉菌病
Acquired immunodeficiency syndrome
Disseminated penicilliosis marneffei
