摘要
目的:探讨血清CA19-9,CA-50,CEA联合检测对胰腺癌的诊断价值。方法:采用酶联免疫测定法和CA-50抗原免疫放射分析法对27例胰腺癌、19例肝癌和37例胃肠癌、30例消化道良性疾病患者血清CA-19、CA-50和CEA水平进行测定,并对胰腺癌、肝癌、胃肠癌及消化道良性疾病患者血清三项标志物的水平进行比较。结果:消化道恶性肿瘤组的血清CA19-9、CA-50、CEA水平明显高于消化道良性疾病组(P<005),尤以胰腺癌为著(P<001)。还发现肿瘤三项标志物联合测定阳性者(CEA>12ng/ml、CA19-9>37u/ml、CA-50>20u/ml三项中两项超过正常值或单项超过其两倍以上者)胰腺癌组占8889%,与其单检阳性率(4444%)相比有显著性差异(P<0005)。肝癌与胃肠癌两组的肿瘤标志物联检阳性率与单检阳性率相比均无显著性差异(P>005)。结论:血清CA19-9、CA-50和CEA联合检测对胰腺癌的诊断有重要价值。
Objective: To investigate the diagnostic value of collective determination of serum CA 19-9, CA-50 and CEA for pancreatic cancer. Methods: The levels of serum CA 19-9, CA-50 and CEA were determined in 27 patients with pancreatic cancer, 19 patients with liver cancer, 37 patient with gastroenteric cancer and 30 patients with benign gastroenteric disease by using microparticle enzymeimmunoassay and radio immunoassay, and the results obtained by both the assays were compared. Results: The levels of serum CA 19-9, CEA and CA-50 in malignant gastroenteric tumor group especially in pancreatic cancer group (P<0 01) were significntly higher than that in benign gastroenteric disease group. Total positive of the three tumor markers or two of three markers higher than normal value or one of three markers twice higher than normal (CEA>12ng/ml,CA 19-9>37 u/ml, CA-50>20 u/ml) in pancreatic cancer group accounted for 88.89% (24/27), and showed statistically different (P<0 005),if comparing these with single determination positive group (44 44%) and no statistical difference between liver cancer group and gastroenteric cancer group (P>0 05),Conclusion:The collective determination of serum CA 19-9,CEA,CA-50 can be of great value for diagnosis of malignant gastroenteric tumor, especially for pancreatic cancer, and can therefore improve the correct diagnosis rate of pancreatic cancer.
出处
《宁夏医学院学报》
2000年第1期13-15,共3页
Journal of Ningxia Medical College
关键词
胰腺肿瘤
血清诊断
CA19-9
CA-50
CEA
pancreatic cancer
collective determination
microparticle enzyme-immunoassay
radio immunoassay
