摘要
本文选择21例住院病人,随机分为两组:第一组11例,先给予狄戈辛0.25mg,每日一次,达稳态血浓度后加服心律平;第二组先给予心律平450或600mg,分三或四次口服,达稳态血浓度后加服狄戈辛。从结果可以看出心律平可显著地增加狄戈辛的血清浓度(p<0.01),平均增加83.84%,但狄戈辛对心律平的血浆浓度无明显的影响(p>0.05)。为了防止不良反应的发生,临床上将狄戈辛与心律平联合应用时,应适当地减少剂量,并对狄戈辛和心律平的血药浓度进行监测。
21 hospitalized patients were randnmized into two groups.The first group included 11 cases given digoxin in a dose of 0.25 mg qd,with propafenone added when the concentration of digoxin reached steady steate. The second group contained 10 cases given propafenone in doses ranging 450 or 600 mg tid or qid, with digoxin added afterwards. The resulis indicated that propafenone markedly increased the serum concentration of digoxin (p<0.01). The average level of increase is 83.84%.However, on the other hand, the plasma concentratration of propafenonewas not influenced by digoxin (p>0. 05). The study indicated that in or-der to prevent the occurence of side efffects and toxicity of digoxin, thedose of digoxin should be reduced and its coecentration monitered whenit was adminstered simutaneously with propafenone.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1990年第3期183-185,143,共4页
The Chinese Journal of Clinical Pharmacology
关键词
洋地黄
心律平
狄戈辛
相互作用
drgoxin
digitalis
propafenone
durgs interaction
