摘要
目的明确载脂蛋白B(ApoB)水平在初诊糖尿病患者中的变化及意义。方法对随诊糖尿病患者连续3年采用免疫比浊法进行低密度脂蛋白(LDL)、ApoB、载脂蛋白A(ApoA)水平测定。结果第3年ApoB水平同前2年相比增高差异有统计学意义(P<0.01)。同未服用他汀类药物患者相比,服用他汀类药物患者的第2年及第3年ApoB水平降低,差异有统计学意义(P<0.05或P<0.01)。结论他汀类药物影响ApoB的生成,ApoB可以作为糖尿病患者心血管疾病的危险性预示指标。
Objective To define the change and significance of apolipoprotein B（ApoB） level in patients with newly diagnosed diabetes.Methods The serum level of ApoB was detected in diabetes patients using immune turbidimetry and then the patients were followed up for 3 years.Results In 49 patients,the ApoB level increased significantly in the third year,the difference was statistically significant compared to the previous two years（P0.01）.The ApoB level reduced in the second and third years in patients taking statins compared to the patients not taking statins（P0.05 or P0.01）.Conclusion Statin drugs affect the generation of ApoB,therefore,can serve as a prediction indicator for cardiovascular disease risk in diabetic patients.
出处
《实用临床医药杂志》
CAS
2012年第5期97-98,101,共3页
Journal of Clinical Medicine in Practice
