摘要
目的观察普瑞巴林治疗枕神经痛的疗效及安全性。方法将80例枕神经痛患者,随机分为治疗组（n=40）和对照组（n=40）。对照组常规予以非甾体类消炎镇痛药、活血化瘀及B族维生素等治疗,治疗组在此基础上加用普瑞巴林75~150 mg,2次/d。2组均观察3周,分别于治疗前及治疗后的1、2、3周进行自评、医评分值评价和临床疗效评价,判断普瑞巴林的疗效及安全性。结果 2组治疗前自评和医评分值比较。差异无统计学意义（P〉0.05）;2组治疗后1、2、3周,治疗组与对照组自评和医评分值比较,差异有统计学意义（P〈0.05）;临床疗效：治疗组有效率92.5%;对照组有效率52.5%,2组比较差异有统计学意义（P〈0.05）。两组均未发现严重副作用。结论普瑞巴林能有效改善枕神经痛患者的临床症状,副作用小,值得临床推广应用。
Objective To observe the efficacy and safety of pregabalin for occipital neuralgia.Methods Eighty patients were randomized to treatment group（n=40） and control group（n=40）.Patients in the control group received nonsteroidal anti-inflammatory drugs,blood-activating and stasis-resolving medicine,and vitamin B.Based on the treatment for the control group,the patients in the treatment group additionally received pregabalin,75-150 mg,bid.The numeric rating scale（NRS） score measured by patients,behavioral rating scale（BRS） score by doctors and clinical efficacy score were recorded before and 1,2,3 weeks after therapy.Results There was no statistical difference in NRS and BRS score before therapy between the two groups（P0.05）.However,statistical difference was observed in NRS and BRS scores 1,2,3 weeks after therapy between the two groups（P0.05）.The clinical efficacy rate was 92.5% in the treatment group,and 52.5% in the control group.There was a statistical difference between the two groups（P0.05）.No severe side effects were found in the study.Conclusion Pregabalin is effective and safe for occipital neuralgia.
出处
《实用临床医药杂志》
CAS
2012年第5期75-77,共3页
Journal of Clinical Medicine in Practice
关键词
普瑞巴林
枕神经痛
临床疗效
pregabalin
occipital neuralgia
clinical efficacy
