摘要
恶性肿瘤、癫痫、老年痴呆、脑缺血等脑部疾病,致残、致死率均很高。目前对治疗该类疾病的药物研发较多,应用成效较为明显,但是由于许多药物不能够通过血脑屏障或通过量较少,达不到控制疾病的作用,因此颅内病变治疗效果差。以冰片为代表的芳香开窍中药有效成分脂溶性强、相对分子质量极小,易挥发,易快速透过血脑屏障进入脑组织,还可促进其他中枢治疗性药物透过血脑屏障,该药对脑组织的损害性小并且具有双向调节血脑屏障通透性的作用,对治疗脑部疾病有重要的理论意义和应用价值。
Malignant tumor,epilepsy,dementia,cerebral ischemia and other brain diseases have very high rates of disability and mortality.Currently,many drugs are developed to treat such diseases and the effect is obviously.But they can not achieve the purpose to control these diseases because many of the drugs can not pass through the blood-brain barrier（BBB）.Therefore,the treatment is not good.Borneol as the represent of the aromatic resuscitation medicine,it has strong fat-soluble active ingredients,small molecular weight,volatile and through the BBB quickly.It can also promote other therapeutic drugs through the BBB.It has two-ways regulations on BBB permeability and the damage of brain tissue is small,this have important theoretical significances and application values.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第7期878-881,共4页
China Journal of Chinese Materia Medica
关键词
冰片
血脑屏障
脑部疾病
borneol
blood brain barrier
brain diseases
