摘要
从一株无活性链霉菌1254经诱变后得到的变株113的发酵液中分离到一组新蒽环类抗生素──变活霉素。变活霉素A为其主要成分;其对疱疹病毒Ⅰ、Ⅱ,流感病毒甲及柯萨奇病毒B_6有明显抑制作用,对某些革兰氏阳性菌亦有活性。 基于光谱证据及化学反应,阐明了变活霉素A的结构。通过 CD谱的比较,NOE差谱及~1HNMR数据的分析以及变活霉素A水解产物环状异丙叉醚衍生物的制备,确定了变活霉素A“A”环立体化学为7S、9R,“A”环呈半椅式构象,C-9在蒽醌环平面上方。
A new anthracycline antibiotic, mutactimycin A, was isolated from the fermentation broth of mutant 113 which was obtained by mutation of a native ant biotic non-producing strain, Streptomyces sp. 1254. It is active against Herpes simplex virus Ⅰ and Ⅱ, Influenza virus A, Coxsackie virus B6 and some G( + )bacteria.
Based on spectral evidence and chemical reactions, the structure of mutactimycin A has been assigned as formula(l). The comparison of CD spectrum of mutactimycin A with that of daunomycin, mutactimycinone A1 and A2; the preparation of cyclic isopro-pylidene ether derivative, of mutactimyciaone A1; the analysis of NOE difference spectra of mutactimycinone A2 and mutactimycin A indicated that C7 and C9 of mutactimycin A have S and R configuration, respectively. 'A'ring of mutactimycia A has a half-chair comformation, with C9 situated abovs the anthraquinone plane.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1990年第6期399-406,共8页
Chinese Journal of Antibiotics
