摘要
目的探讨瑞舒伐他汀对经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后患者血清脂联素(adiponectin,APN)和超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)的影响。方法 108例成功进行PCI治疗的患者随机分为两组。对照组46例仅常规治疗,瑞舒伐他汀处理组62例在常规治疗基础上,每晚口服瑞舒伐他汀10 mg。观察PCI术前、术后1天、1月、3月、6月血APN及hs-CRP水平,并进行比较和相关分析。结果两组PCI术前及术后1天血APN和hs-CRP水平差异无统计学意义(P>0.05)。术后1月、3月、6月与术后1天相比,两组血APN水平均升高,hs-CRP水平均下降;与对照组比较,瑞舒伐他汀组术后血APN水平明显升高,而hs-CRP水平显著下降,差异均有统计学意义(P<0.01)。血APN与hs-CRP水平呈负相关(r=-0.330,P<0.05)。结论瑞舒伐他汀在冠状动脉支架植入术后能显著提高血APN水平,降低hs-CRP水平,预防和延缓PCI术后再狭窄。
Objective To investigate the effect of rosuvastatin on serum adiponectin（APN） and high-sensitivity C-reactive protein（hs-CRP） on patients after percutaneous coronary intervention（PCI）.Methods One hundred and eight patients with successful PCI were randomly divided into control group（46 cases） accepting conventional therapy and rosuvastatin group（62 cases） with oral administration of 10mg rosuvastatin each night besides the conventional therapy.Serum APN levels and hs-CRP levels were observed before PCI,one day,1 month,3 months and 6 months after PCI.Comparison and correlation analysis was performed.Results There was no significant difference in serum APN and hs-CRP levels between the two groups before PCI and one day after PCI（P0.05）.Serum APN levels were significantly increased and hs-CRP levels were obviously decreased in two groups 1 month,3 months and 6 months after intervention compared with those 1 day after PCI.Serum APN concentration was significantly higher in rosuvastatin group than that in control group,and blood hs-CRP level was significantly lower than that in control group（P0.01）.The blood APN levels were negatively related with hs-CRP levels（r=-0.330,P0.05）.Conclusion Rosuvastatin can significantly improve serum APN levels and decrease hs-CRP levels in the patients with coronary stent implantation so as to prevent and delay restenosis after PCI.
出处
《华南国防医学杂志》
CAS
2011年第6期506-508,共3页
Military Medical Journal of South China
基金
全军医学科学技术"十一五"计划课题(调整项目)
关键词
瑞舒伐他汀
冠状动脉支架植入术
超敏C反应蛋白
脂联素
Rosuvastatin
Coronary stent implantation
High-sensitivity C-reactive protein
Adiponectin
