摘要
目的:制备龙血竭结肠定位片,并评价其体外释药情况。方法:制备龙血竭含药片芯,采用HPMC,EC与丙烯酸Ⅱ号树脂等制备龙血竭结肠定位片。单因素试验考察药物释放的影响因素,确立处方组成,采用正交设计对包衣液处方进行优化。结果:最佳包衣处方为溶胀层增重3%,肠溶层增重2%,丙烯酸Ⅱ号树脂与EC比值1∶10,结肠定位片的时滞6 h,时滞5 h后累积释药达80%。结论:龙血竭结肠定位片在体外具有结肠定位释放的特性,能达到治疗结肠部位疾病的目的。
Objective：Longxuejie colon-target tablet were prepared and investigated its in vitro release property.Method：Prepared core tablet containing Dranaena cochinchinensis,this colon-target tablet was prepared by hydroxypropylmethylcellulose,ethylcellulose and polyacrylic resin Ⅱ.Coating formulation was established with investigating drug release by single factor test,and orthogonal design was used to optimized coating formulation.Result： Optimal coating formulation was 3% weight gain of swelling coating layer,2% weight gain of enteric coating layer,polyacrylic resin Ⅱ-ethylcellulose 1∶10,colon-target tablet had a lag time of 6 hours and cumulative release quantity reached to 80% within 5 hours.Conclusion： Longxuejie colon-target tablet had colon-release characteristics,and could achieve the purpose of treatment of colon site disease.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第7期43-47,共5页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
龙血竭
结肠定位片
薄膜包衣法
正交设计
丙烯酸Ⅱ号树脂
Dranaena cochinchinensis
colon-target tablet
film coating method
orthogonal design
polyacrylic resin Ⅱ
