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流行性感冒相关细胞因子的研究进展 被引量：9

Cytokines profiles post influenza virus infection
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摘要 流行性感冒(简称流感)是由流感病毒引起的一种急性上呼吸道传染病,其中甲型流感病毒因抗原变异率高而受到广泛关注。流感病毒感染机体后,一方面,细胞因子参与机体抗流感病毒免疫应答,发挥免疫调节作用,即在天然免疫阶段,白细胞介素和肿瘤坏死因子α等炎性细胞因子参与调节机体免疫应答强度、介导炎症反应的发生,并启动适应性免疫应答,最终清除流感病毒;另一方面,炎性细胞因子的过度表达会引发细胞因子表达失调,对机体造成严重的病理损伤。 Influenza is an acute upper respiratory tract infection caused by the influenza virus and regulated by the host immune system. Throughout the whole infectious process, interleukins and tumor necrosis factor a （TNF-α） are actively involved in the regulation of innate immune response, activation of adaptive immunity, levels of reactions and clearance of pathogens. On the other hand, hyperactivation of inflammatory cytokines may lead to severe immunopathological damage.
作者 王嘉瑜 俞雪莲 张曦
机构地区 上海市疾病预防控制中心
出处 《微生物与感染》 2012年第1期62-66,共5页 Journal of Microbes and Infections
基金 "十一五"国家科技重大专项(2008ZX10401) 上海市科委生物医药重大项目(09DZ1906600)
关键词 流行性感冒病毒 细胞因子 免疫调节 免疫病理损伤 Influenza virus Cytokine Immunoregulation Immunopathological damage
分类号 R511.7 [医药卫生—内科学]
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参考文献42

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共引文献61

同被引文献87

  • 1林文实,郑思轶.香港流行性感冒与天气的关系[J].环境与健康杂志,2004,21(6):389-391. 被引量：24
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微生物与感染
2012年 第1期

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