摘要
成功的妊娠需要适当的母胎免疫耐受。随着妊娠的进展,孕酮作为一种免疫调节因子,作用于子宫内膜上皮细胞、基质细胞及子宫螺旋动脉,提供妊娠所需要的子宫微环境,并调节蜕膜树突细胞、T细胞与自然杀伤细胞的活性,上调滋养细胞膜人类白细胞抗原G免疫表达,诱导免疫耐受。因此,母体内孕酮的水平对正常妊娠的维持至关重要。
It is necessary to develop the proper fetal-maternal immune tolerance for successful pregnancy. Along with the development of pregnancy, progesterone, as a kind of immune regulatory factor, acts on end- ometrial epithelial and stromal cells and spiral arteries, which provides the uterine micro nvironment for pregnancy. Meanwhile, progesterone regulates the activities of dendritic ceils, T cells and natural killer cells in deciduas, and up egulates human leukocyte antigen G gene expression. The effects of progesterone synthetically induced the immune tolerance. Thus, progesterone is critical for the maintenance of pregnancy.
出处
《国际生殖健康／计划生育杂志》
CAS
2012年第2期133-136,共4页
Journal of International Reproductive Health/Family Planning
关键词
孕酮
免疫系统
妊娠
流产
自然
Progesterone
Immune system
Pregnancy
Abortion, spontaneous
