摘要
目的 研究米非司酮配伍米索前列醇对母胎界面孕酮诱导阻断因子（PIBF）及孕酮受体（PR）表达的影响. 方法 应用免疫组织化学染色法检测米非司酮药物流产成功（药流成功组,n =30）、失败（药流失败组,n=30）及正常早孕负压吸宫流产（手术组,n=30）绒毛及蜕膜组织中PIBF及PR的表达情况. 结果 PIBF表达于绒毛合体滋养层细胞、细胞滋养层细胞和蜕膜细胞胞质,PR表达于蜕膜组织细胞核.与手术组相比,药物流产的两组绒毛滋养层细胞中PIBF的表达差异无统计学意义,而在蜕膜细胞中,药物流产的两组PIBF、PR的表达明显下降,差异有统计学意义,且药流成功组PIBF及PR的表达低于药流失败组,差异有统计学意义. 结论 米非司酮配伍米索前列醇终止早期妊娠可能与PIBF及PR的表达降低有关,其成功率与PIBF、PR表达降低程度相关.
Objective To study the anti-early pregnancy mechanism of mifepristone and misoprostol by investiga- ting the expression of progesterone-induced blocking factor （PIBF） and progesterone receptor （PR） in the maternal-fetal interface of early pregnancy. Methods PIBF and PR were investigated with immunohistochemistry in 3 groups, inclu- cling group A （ successful medical abortion, n = 30）, group B （ failure medical abortion, n = 30） and group C （ induced a- bortion with vacuum aspiration, n = 30）. Results PIBF was mainly detected in the cytoplasm of syncytiotrophoblastie, cytotrophoblastic and decidual cells, and PR expressed on decidual cell nucleus. The expression of PIBF and PR in decidu- as of group A and B was lower than group C, with no difference of PIBF expression in villus. Both PIBF and PR had lower expression level in group A than in group B. Conclusion Mifepfistone may prevent pregnancy by lowering the expression of P1BF and PR in the maternal-fetal interface of early pregnancy, and the success rate of pregnancy was associated with the decline in their expression.
出处
《中国生育健康杂志》
2014年第1期33-36,F0003,共5页
Chinese Journal of Reproductive Health
关键词
米非司酮
孕酮诱导阻断因子
孕酮受体
Mifepristone
Progesterone-induced blocking factor
Progesterone receptor
