摘要
目的探讨乌司他丁(UTI)联合血必净(XBJ)对内毒素(LPS)致多脏器功能障碍综合征(MODS)的防治作用。方法将50只绵羊随机分为对照组(A组)、模型组(B组)、乌司他丁组(C组)、血必净组(D组)和乌司他丁+血必净组(E组),每组10只。利用LPS建立MODS模型,并以UTI、XBJ和UTI+XBJ进行防治。观察各组的体征表现,测定不同时点各组的血气、血常规、血清生化指标的改变。结果 UTI+XBJ组绵羊的体征表现明显减轻、死亡率明显降低,PaO2、生化指标和白细胞数目得到了有效的控制。结论乌司他丁联合血必净较单独应用能明显改善LPS诱导的MODS动物体征表现、降低死亡率,对肺脏、肝脏和肾脏等多脏器损伤具有良好的防治作用。
Objective To investigate prevention and cure effect of Ulinastatin（UTI） combined with XUEBIJING（XBJ） on multiple organ dysfunction syndrome（MODS） induced by lip polysaccharide（LPS） in sheep.Methods 50 sheep were randomly separated into 5 groups ： the control（Group A）,model group（Group B）,UTI group（Group C）,XBJ group（Group D） and UTI ＋ XBJ group（Group E）,10 sheep each group.The MODS model was established by LPS in sheep.It was prevented and cured by UTI,XBJ and UTI ＋ XBJ.Then the physical sign appearance was observed and the indexes of blood gas,blood routine and blood biochemistry were determined in each group.Results The sheep in UTI＋XBJ group,the physical sign appearance was obviously alleviative,the death rate was markedly degraded.Arterial oxygen pressure（PaO2）,the biochemical indexes and the number of WBC was regulated efficiently.Conclusion UTI ＋ XBJ could improve obviously physical sign appearance,degrade the death rate and it had favourable preventive and therapeutic effect on damage in multiple organ.
出处
《中国比较医学杂志》
CAS
2012年第3期23-27,31,共6页
Chinese Journal of Comparative Medicine
基金
甘肃省自然科学基金(No.1010RJZA052)
