摘要
目的探讨新生儿败血症患者外周血白细胞表面Mac1、ICAM-1在发病中的作用。方法采用全血直接免疫荧光流式细胞术检测30例新生儿败血症患者及20例正常小儿外周血白细胞表面粘附分子(AMS)Mac1、ICAM-1的表达。结果除PMN表面Mac1的PPC外,其他各组Mac1、ICAM-1的PPC及MFI比较均有统计学意义,随病情的加重有升高的趋势,以M表面的AMS上调最为显著(P<0.05或0.01)。结论 AMS在新生儿败血症的发病中发挥了重要作用;白细胞表面ICAM-1表达上调的水平有可能作为判断新生儿败血症病情程度的免疫学指标。
Objective To explore the expressions of Mac1 and ICAM-1 of the peripheral blood leukocyte surface（PBLS） in newborns with septicemia.Methods The whole blood direct immunofluorescence flow cytometry was used to detect the expressions of Mac1 and ICAM-1 of PBLS in 30 infants with septicemia and in 20 control infants.Results Except the Mac1＇s PPC on PMN,Mac1 and ICAM-1＇s PPC and MFI in other groups were statistically significant.As the disease worsens,the expressions of AMS rose most significantly（P0.05 or 0.01）.Conclusion The expressions of adhesion molecule surface（AMS） might play an important role in the attack of septicemia.The rise in the expressions of ICAM-1 on PBLS might be an immunological index to reflect the condition of neonatal septicemia.
出处
《山东医学高等专科学校学报》
2012年第1期15-18,共4页
Journal of Shandong Medical College
