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血红素氧合酶-1与中枢神经系统疾病 被引量：1

Heme oxygenase-1 and central nervous system diseases
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摘要 血红素氧合酶-1(heme oxygenase-1,HO-1)是血红素降解的起始酶和限速酶,可被氧化应激、化学物质和药物等诱导激活,通过抗氧化、抗炎和抗凋亡机制发挥细胞保护作用。多种中枢神经系统(central nervous system,CNS)疾病均可引起HO-1表达变化,该酶的异常涉及到多种CNS疾病。文中就HO-1的生物学特性和在不同神经系统疾病中的表达、作用作简要综述。 Heme oxygenase-1（HO-1）,as a rate-limiting enzyme of heme,can be activated by oxidative stress,chemical materials and drugs,and protects cells by its anti-oxidation,anti-inflammation and anti-apoptosis roles.Its abnormal expression is always related to many central nervous system diseases.This article summarizes the biological specificities and its expressions and effects in different central nervous system diseases.
作者 李丹 段满林
机构地区 南京军区南京总医院麻醉科
出处 《医学研究生学报》 CAS 北大核心 2012年第3期316-320,共5页 Journal of Medical Postgraduates
关键词 血红素氧合酶 中枢神经系统疾病 氧化应激 缺血再灌注损伤 Heme oxygenase Central nervous system disease Oxidative stress Ischemia-reperfusion injury
分类号 R741.05 [医药卫生—神经病学与精神病学]
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参考文献43

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二级参考文献99

共引文献29

同被引文献17

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医学研究生学报
2012年 第3期

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