摘要
目的评价依托考昔治疗骨关节炎的有效性和安全性。方法采用随机对照研究的方法,将60例患者分为治疗组和对照组各30例。治疗组每天早餐后口服依托考昔60 mg,对照组每天早、午、晚餐后各服双氯芬酸50 mg,治疗6周,对治疗前、治疗3周及治疗6周时两组的VAS评分进行比较,同时观察药物的不良反应。结果治疗组初次服药后4 h VAS评分低于对照组,差异有统计学意义(P<0.01),两组在治疗前及治疗后3、6周的VAS评分比较,差异均无统计学意义(P>0.05)。两组总的不良反应发生率比较,差异无统计学意义(P>0.05),但两组胃肠道不良反应发生率比较,治疗组低于对照组(P<0.05)。结论在骨关节炎治疗上,依托考昔60 mg日1次与双氯芬酸钠50 mg日3次的疗效相当,但依托考昔起效快,且胃肠道不良反应小。
Objective To observe the effect and safety of etoricoxib in treating osteoarthritis.Methods Osteoarthritis patients were randomised to receive either etoricoxib 60 mg once daily（n=30） or diclofenac 50 mg three times daily（n=30） for 6 weeks,Analgesia score were measured by the method of visual analogue scale（VAS）at 4 hour,3 weeks and 6 weeks after receiving either diclofenac or etoricoxib,and the side effect of the drugs was observed.Results VAS scores of etoricoxib group were lower at 4 hours than that of the control group（P0.01）,but no differences of VAS score were found before treatment、3 weeks and 6 weeks after treatment between the two groups（P0.05）.The general incidences of adverse reactions were not different in the two groups（P0.05）.but the incidences of gastrointestinal disorders were lower in etoricoxib group than those of the control group（P0.05）.Conclusion Etoricoxib 60 mg once daily is clinically effective in the therapy of osteoarthritis providing a magnitude of effect comparable to that of diclofenac 50 mg three times daily.The onset of clinical benefit with etoricoxib is more rapid than that of diclofenac,and etoricoxib can be tolerated better than diclofenac.
出处
《实用药物与临床》
CAS
2012年第3期132-134,共3页
Practical Pharmacy and Clinical Remedies
关键词
依托考昔
骨关节炎
镇痛
Etoricoxib
Osteoarthritis
Analgesia
