10Aledort L,Haschmeyer RH,Pettersson H.A longitudinalstudy of orthopaedic outcoraes for severe factor VIII-deftcienthaemophiliacs[J].J Intern Med,1994,236(4):391-394.
2[1]KASPER CK.Concentrate safety and efficacy[J].Hemophilia,2002,8:161-165.
3[2]EVATT B.L.,BLACK C,BATOROVA A,et al.Comprehensive care for hemophilia around the world[J].Haemophilia,2004,10,(Suppl.4):9-13.
4[3]CARCAO MD,ALEDORT LM.Prophylaxis in the hemophilia population-optimizing therapy[J].Haemophilia,2007,13:227 232.
5[4]MANCO-JOHNSON MJ,PETTERSSON H,PETRINI P,et al.Physical therapy and imaging outcome measures in a hemophilia population treated with factor prophylaxis:current status and future directions[J].Hemophilia,2004,10 (Suppl.4):88-93.
4DiScipio RG, Davie EW. Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and humanplasma [J]. Biochemistry, 1979 , 18(5) : 899-904.
5McMullen BA, Fujikawa K, Kisiel W, et al. Complete amino acidsequence of the light chain of human blood coagulation factor X :evidence for identification of residue 63 as beta- hydroxyasparticacid [J]. Biochemistry, 1983,22(12) : 2875-2884.
6Kaufman RJ,Wasley LC, Furie BC, et al. Expression,purification, and characterization of recombinant 7-carboxylatedfactor IX synthesized in Chinese hamster ovary cells [ J]. J BiolChem, 1986,261(21) : 9622-9628.
8Hirosawa S, Fahner JB, Salier JP, et al. Structural and functionalbasis of the developmental regulation of human coagulation factorIX gene: factor ]X Leyden [ J] . Proc Natl Acad Sci U S A, 1990,87(12): 4421-4425.
9Kurachi S,Hitomi Y,Furukawa M,et al. Role of intron I inexpression of the human factor DC gene [J]. J Biol Chem, 1995,270(10); 5276-5281.
10Kurachi K, Davie EW. Isolation and characterization of a cDNAcoding for human factor IX [ J ]. Proc Natl Acad Sci USA,1982, 79(21) : 6461-6464.