摘要
目的探讨幽门螺杆菌(Hp)感染对冠心病(CHD)患者血清溶性细胞间黏附分子1(sICAM-1)、白细胞介素6(IL-6)和高敏C-反应蛋白(hs-CRP)等炎症因子表达水平变化的影响。方法选择2010年3月-2011年4月于医院健康体检中心查体的CHD患者45例为研究对象,另选择30名健康体检者为对照组,采用酶联免疫吸附法(ELISA)检测HpIgG、sICAM-1、IL-6及hs-CRP的表达水平,分析Hp感染与sICAM-1、IL-6及hs-CRP表达变化之间的关系。结果 CHD组患者Hp-IgG阳性率为75.6%、血清sICAM-1(509.56±63.45)μg/L、IL-6(37.29±14.69)ng/L及hs-CRP(8.26±3.68)mg/L的表达水平均显著高于对照组的50.0%,(154.24±27.39)μg/L、(15.63±6.84)ng/L及(4.72±2.38)mg/L,差异有统计学意义(P<0.05),Hp感染阳性CHD患者的血清sICAM-1(615.86±89.45)μg/L、IL-6(44.09±13.49)ng/L及hs-CRP(10.52±3.48)mg/L表达水平均明显高于Hp感染阴性患者的(395.72±71.49)μg/L、(25.93±9.83)ng/L、(5.91±2.18)mg/L,差异有统计学意义(P<0.05)。结论 Hp感染与CHD的发生有关,Hp感染可能通过激发血清sICAM-1、IL-6及hs-CRP表达水平而加重冠状动脉内炎症反应,参与动脉粥样硬化的病理过程。
OBJECTIVE To explore the effects of Helicobacter pylori（Hp） in serum inflammatory factors in coronary heart disease（CHD）.METHODS Forty five cases with CHD were selected as CHD group and 30 healthy cases as control group.Serum specific antibodies to Hp（Hp-IgG）,serum sICAM-1,IL-6 and hs-CRP were measured in control group and CHD group by ELISA.The relationship of Hp and the expression of serum sICAM-1,IL-6 and hs-CRP were analyzed.RESULTS The positive rate of Hp IgG（75.6%） and the expression of serum sICAM-1（509.56±63.45）,IL-6（37.29±14.69） and hs-CRP（8.26±3.68） in CHD group were significantly higher than those in control group（50.0%,154.24±27.39,15.63±6.84,4.72±2.38）（P0.05）.In CHD group,those who were Hp IgG positive had significant higher levels of sICAM-1（615.86±89.45）,IL-6（44.09±13.49） and hs-CRP（10.52±3.48） than those who were Hp IgG negative（395.72±71.49,25.93±9.83,5.91±2.18）（P0.05）.CONCLUSION There is significant corelation between Hp infections and CHD.Hp infections may be involved in the pathogenesis of atherosclerosis and myocardial infarction by increasing the expression of sICAM-1,IL-6 and hs-CRP and aggravating coronary artery inflammation.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第6期1207-1209,共3页
Chinese Journal of Nosocomiology
