摘要
目的了解医院药品不良反应(ADR)发生的特点,以促进临床合理用药。方法对医院2008年至2010年收集的389例药品不良反应报告,采用Excel电子表和手工筛选方法进行统计、分析。结果389例报告中,60岁及以上人群所占比例最大,有201例(占51.67%);女性患者发生药品不良反应的几率明显较男性高;涉及的药品中,中成药和中药注射剂、循环系统用药、抗微生物药的药品不良反应发生率高(各占22.88%,22.88%,12.85%);药品不良反应临床表现以消化系统反应最多(28.79%);新的严重的药品不良反应5例(1.29%);好转303例,治愈86例,无死亡病例。结论中成药和中药注射剂、循环系统用药、抗微生物药是药品不良反应监测工作的重点,临床应加强药品不良反应监测,提高合理用药水平。
Objective To probe into the characteristics of adverse drug reaction （ADR） occurred in our hospital in order to promote rational drug use in clinic. Methods 389 ADR cases collected from our hospital from 2008 to 2010 were analyzed statistically by Excel electronic sheets and manual screening. Results Of 389 ADR cases, the patients aged over 60 occupied great proportions （201 cases, 51.67% ）.The ADR incidence of female patients was higher than that of male. ADR cases were mainly caused by Chinese patent medicines and TCM injections （22. 88% ）, cardiovascular drugs （22.88%） and antimierobial drugs （12.85%）.Gastrointestinal reactions were the most common clinical manifestations （28.79%）. There were 5 cases （1.29%） of new severe ADR. 303 cases were improved and 86 cases were cured. There was no death case. Conclusion Chinese patent medicines and TCM injections, cardiovascular drugs, antimicro- hial drugs are key point of ADR monitoring. Great importance should be attached to ADR monitoring to promote rational use of drugs.
出处
《中国药业》
CAS
2012年第6期55-56,共2页
China Pharmaceuticals
