摘要
目的探讨肌钙蛋白T和肿瘤坏死因子对充血性心力衰竭患者心肌损伤和预后的评价意义。方法对 2 2例心功能Ⅲ级、12例心功能Ⅳ级的心衰患者和 2 5例正常人的血清cTNT、TNF和心肌酶作了对比研究。结果CHF者的TNF与cTNT值呈显著正相关 (r =0 5 5 18,P <0 0 1) ;心衰组各测定值异常检出率为cTNT97 45 % ,TNF88 2 3 % ,CK11 76 % ,CK -Mb41.17% ,AST76 .47% ;并随心衰加重cTNT、TNF异常检出率增高 ,心功能Ⅳ级cTNT为 10 0 % ,Ⅲ级为 95 45 % ;TNF心功能Ⅳ级 91 16 % ,Ⅲ级为 86 36 %。结论血清cTNT、TNF监测对判断心衰患者心肌损伤是一个高度敏感和特异的指标 。
Objective Evaluation of significance in troponinT(TNT) and tumor necroses factor(TNF) on myocardial damage and prognoses of patient with congestive heart failure.Methods cTNT,TNF and myocardial enzymes in serum from 22 cases with cardiac function Ⅲ degree, 12 cases with cardiac function Ⅳ degree and 25 normal persons were comparated. Results TNF and TNT of patient with CHF had a significant positive relation(r=0.5518,P<0.01),the abnormal detectable rate of value in each group of heart failure were cTNT 97.5%, TNT 88.23%,CK 11.76%,CKMb 41.17%,AST 76.4%.The abnormal detectable rate was increased in severe cardiac failure patients, the cTNT of cardiac function Ⅳ and Ⅲ degree were 100% and 95.45% respectively, the TNF of cardiac function Ⅳ and Ⅲ degree were 91.6% and 86.36% respectively. Conclution The cTNT, TNF in serum were index of high sensibility and specificity for judgement the damage of myocardium.
出处
《贵州医药》
CAS
2000年第1期3-5,共3页
Guizhou Medical Journal
