摘要
本文报告了用马来丝虫成虫冰冻切片抗原作 IFAT 检测班氏丝虫微丝蚴血症者抗体阳性率为88.89％;非流行区健康居民抗体阳性率为3.92％。基本消灭丝虫病后8年的地区原微丝蚴血症者和阴性居民抗体阳性率分别为13.54％和10.84％;基本消灭后15年原微丝蚴血症者和阴性居民抗体阳性率分别为6.45％和5.16％;基本消灭后24年原微丝蚴血症者和阴性居民抗体阳性率分别为3.67％和3.96％。基本消灭丝虫病后15年的地区人群抗体阳性率已降到非流行区健康人群水平(X^2=0.48 P>0.05)。因此认为 IFAT 可作为我省丝虫病防治后期和基本消灭丝虫病后流行病学监测的主要方法之一。此外,观察到微丝蚴血症者血清抗体阳性率和阳性 GMRT 与微丝蚴密度无相关性。
Indirect fluorescent antibody test(IFAT)using frozen sections of Brugia malayi adult worms as antigen was employed for detecting the antibody.Sera collected from bancroftian microfilaremias and the healthy people from non-endemic area were tested with the positive rate of 88.89% and 3.92% respectively. Observation on the change in population antibody level in various controlled areas was made.The results were as follows:a)in the area 8 years after filariasis had been got under control,the positive rates in IFAT for examining the former microfilar- emias and the negative inhabitants were 13.5% and 10.8% respectively;b)in the area 15 years after the disease had been got under control,the positive rates in the former microfilaremias and negative inhabitants were 6.45% and 5.16% respectively;c)in the area 24 years after the disease had been got under control,the positive rates in the former microfilaremias and negative inhabitants were 3.67% and 3.96% respectively. The results showed that the antibody level in the local population has been kept on reduction year by year after the coatrol of filariasis,and 15 years after the control the antibody level in the population had been equal to that in the non-endemic area.It is considered that IFAT can be used as one of the major methods in sero-epidemiological surveillance after the control of filariasis in our province.No correlation between the circulating microfilarial density and that of the antibody positive rate and GMRT was observed.
出处
《中国寄生虫病防治杂志》
CSCD
1990年第4期290-293,共4页
Chinese Journal of Parasitic Disease Control
