摘要
目的探讨干扰素-γ、白介素-32和白细胞介素-1β在原因不明习惯性流产中的表达及临床意义。方法ELISA法检测URSA组、正常妊娠组和健康对照组血清中IFN-γ、IL-32和IL-1β的浓度,并进行统计学分析。结果URSA组IFN-γ、IL-32和IL-1β的血清浓度水平显著高于健康对照组和正常妊娠组(P<0.01);正常妊娠组较健康对照组的IFN-γ、IL-32和IL-1β血清浓度水平均显著下降(P均<0.01)。结论IFN-γ、IL-1β、IL-32反馈环可能参与了URSA的发生,对其血清浓度的检测可作为监测URSA病人治疗效果和再次妊娠结局的指标。
Objective To explore the expression and the clinical significance of IFN-γ, IL-32 and IL-1β in Unexplained recurrent spontaneous abortion. Methods In method of ELISA to detect the serum level of IFN-γ, IL-32 and IL-1β in healthy control group, URSA group, pathological pregnancy group. Results The serum level of IFN-γ,IL-32 and IL-1β in URSA group are significantly increased as compared with healthy control group and pathological pregnancy group （P 〈 0.01）. The serum level of IFN-γ,IL-32 and IL-1β are significantly lower in pathological pregnancy group than in the healthy control group （P 〈 0.05）. Conclusion The IFN-γ,IL-32,IL-1βfeedback loop maybe involved in Unexplained recur- rent spontaneous abortion.
出处
《中国现代医生》
2012年第10期82-83,85,共3页
China Modern Doctor
基金
浙江省温州市2011年第二期科技计划项目(Y20110208)
