摘要
目的:建立盐酸洛美沙星分散片体外溶出度的测定方法。方法:分别以水、磷酸盐缓冲液(pH6.8)、醋酸盐缓冲液(pH4.0)和盐酸溶液(0.1mol.L-1)为介质,篮法、转速100r.min-1条件下测定盐酸洛美沙星分散片在不同时间点的累积溶出率,采用紫外分光光度法在287nm波长下测定含量,确定溶出度的测定方法。结果:以盐酸溶液(0.1mol.L-1)为介质时,样品溶出更快、更平稳;确定溶出度检查取样时间为15min,限度标准为80%。结论:建立的盐酸洛美沙星分散片的体外溶出度测定方法可行。
OBJECTIVE： To establish the method for the dissolution determination of Lomefloxacin hydrochloride dispersible tablet in vitro. METHODS： Accumulative dissolution rates of Lomefloxacin hydrochloride dispersible tablet at different time points were determined by basket method at rotation speed of 100 r.min-1 using water, phosphate buffer solution （pH 6.8）, acetate buffer solution （pH 4.0） and hydrochloric acid solution （0.1 mol.L-1） as medium. The content of drugs was determined by UV spectro- photometry at 287 nm to determine the dissolution determination. RESULTS： Sample was dissolved more fastly and stable in hydrochloric acid solution （0.1 mol.L-1）. The sampling time of dissolution determination was 15 min and the limit was 80%. CONCLUSION： The method that established for the dissolution determination of Lomefloxacin hydrochloride dispersible tablet was feasible.
出处
《中国药房》
CAS
CSCD
2012年第13期1218-1220,共3页
China Pharmacy
关键词
盐酸洛美沙星分散片
体外溶出度
介质
紫外分光光度法
Lomefloxacin hydrochloride dispersible tablet
In vitro dissolution
Medium
UV spectrophotometry
