摘要
目的探讨胃癌患者血清可溶性血管粘附蛋白-1(sVAP-1)的临床意义。方法入选胃癌患者108例,年龄37～80(52.6±16.4)岁,其中男性68例,女性40例。正常健康者100例,年龄30～78(51.6±18.4)岁,其中男性68例,女性32例。免疫酶联吸附法(ELISA)检测所有研究对象的血清sVAP-1水平。结果 ELISA结果显示胃癌患者血清sVAP-1水平明显高于对照组(P<0.05)。胃癌患者中性别、年龄和是否有淋巴管浸润及静脉浸润与sVAP-1的水平无明显关系(P>0.05)。但是存在淋巴结转移、肝转移、腹腔播散和远处转移的患者血清sVAP-1的水平明显降低(P<0.05)。不同的TNM分期的患者血清SVAP-1水平存在差异(P<0.05)。结论低水平的血清s-VAP与胃癌患者的预后有关。
Objective To discuss the clinical significance of detection of serum soluble vascular attachment protein-1（sVAP-1）in gastric cancer patients.Methods Among the selected 108 gastric cancer patients aged from 37-80（averaged 52.6±16.4）years old,there were 68 male ones and 40 female ones.And 100 healthy people（control group）aged from 30-78（averaged 51.6±18.4）years old were also selected,in which 68 ones were male and 32 ones were female.All the subjects received the detection of sVAP-1 level with enzyme-linked immunospecific assay（ELISA）.Results The detection results showed that the level of sVAP-1 in gastric cancer patients was much higher than that in the control group,and the differences were significant（P〈0.05）.Among the gastric cancer patients,there was no significant correlation between sex,age,lymphovascular invasion and venous invasion and the level of sVAP-1（P〉0.05）.But among the patients with lymph node metastasis,liver metastasis,abdominal cavity dissemination and distant metastasis,their level of sVAP-1 significantly decreased（P〈0.05）.There were significant differences in the sVAP-1 level among the patients with different stages of TNM（P〈0.05）.Conclusion Low sVAP-1 level is correlated with poor prognosis of patients with gastric cancer.
出处
《西南国防医药》
CAS
2012年第3期246-248,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
胃癌
可溶性血管粘附蛋白-1
预后
gastric cancer
soluble vascular attachment protein - 1
prognosis
