摘要
目的应用实时超声造影技术结合时间-强度曲线定量评价不同程度肝硬化患者肾血流灌注情况。方法常规肾功能正常的肝硬化患者40例，据肝功能Child—Pugh分级法分为Child—PughA级组14例，B级组14例，c级组12例。以30例正常人为对照，比较不同程度肝硬化患者肾血流灌注及时间一强度曲线量化参数，并与Child—Pugh评分进行关联性分析。结果与正常组比较，肝硬化组肾皮质血流灌注峰值强度减低，达峰时间延长，曲线下面积减小（P〈0．05）；与A级组比较，B级组峰值强度减低，c级组峰值强度减低、达峰时间延长（P〈0．05或P〈0．01）。峰值强度与肝硬化组Child—Pugh评分呈负相关（r=-0．506，P〈0．01）。结论超声造影结合时间-强度曲线可定量评估不同程度肝硬化患者肾血流灌注，峰值强度与肝硬化的病变程度密切相关。
Objective To assess the renal perfusion of different severity of hepatic cirrhosis by contrast-enhanced ultrasound with time-intensity curve. Methods Forty hepatic cirrhosis patients with normal conventional renal function enrolled the study and were subdivided into Child-Pugh A group （ n = 14） ,Child Pugh B group （ n = 14） and Child-Pugh C group （ n = 12）. Thirty healthy subjects were selected as the control group. The parameters of perfusion were compared among the groups. The correlations between parameters and score of Child-Pugh were analyzed using Pearson correlation. Results The cirrhosis groups showed a decrease of peak intensity,increase of time to peak,and reduce of area under the curve in the renal cortex（ P 〈0.05）. Compared with Child-Pugh A group, the peak intensity decreased in both Child- .Pugh B and C groups,time to peak increased in Child-Pugh C group（ P〈0.05 or P 〈0.01）. The peak intensity had negative correlation with Child-Pugh score（ r = - 0. 506, P 〈0.01）. Conclusions Contrast enhanced ultrasound combined with time-intensity curve can assess renal perfusion of hepatic cirrhosis quantitatively. The peak intensity was correlated to the severity of cirrhosis.
出处
《中华超声影像学杂志》
CSCD
北大核心
2012年第3期213-216,共4页
Chinese Journal of Ultrasonography
基金
基金项目：山西省科技攻关项目（20100311097-3,20110321077-02）
关键词
超声检查
微气泡
肝硬化
肾循环
Ultrasonography
Microbubbles
Liver cirrhosis
Renal circulation
