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细胞衰老与衰老细胞 被引量：10

Cellular Senescence and Senescent Cell
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摘要 细胞衰老(cellular senescence)是一个应激导致细胞生长停滞的生理过程.一部分发生衰老的细胞会被机体自身清除,但另一些衰老的细胞会随着时间的推移在体内积累增多,并分泌一些免疫刺激因子,导致低水平炎症发生,引起周围组织衰老或癌变,这类具有特殊生物学特征和功能的细胞就是衰老细胞(senescent cell).实验揭示,衰老细胞不仅是衰老过程的产物,也可能是组织器官进一步衰退的重要原因.近日,Baker等的一项研究成果(Nature,2011,479(7372):232-236)表明,清除衰老细胞可延缓小鼠的衰老进程,该成果有望开辟出一条对抗衰老的新途径. Cellular senescence is a process that leads to a growth arrest.Some of these cells are cleared after being in a state of alive but lose the ability to divided long time,while some cells（named senescent cell） accumulate in aging tissues,secrete agents that stimulate the immune system and cause low-level inflammation,which may disrupt nearby tissue structure and function even promote cancer progression.A recent report in Nature by Baker et al.introduced a method of delaying aging process by clearing senescent cells in mice.The findings raise the prospect that any therapy that rids the body of senescent cells would protect it from the ravages of aging.
作者 王璞 陈露萍 李清泉 汤奇胜 沈亦雯 朱剑虹
机构地区 复旦大学附属华山医院神经外科 复旦大学医学神经生物学国家重点实验室 复旦大学脑科学研究院 复旦大学上海医学院
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2012年第3期257-263,共7页 Progress In Biochemistry and Biophysics
基金 国家重点基础研究发展计划(973)(2010CB945504 2012CB966300 2009CB941100) 国家自然科学基金(30870805 90919002) 上海市科委基础研究重点项目(08dj1400503)资助~~
关键词 细胞衰老 衰老细胞 p16Ink4a基因 AP20187 干细胞 senescent cell cellular senescence p16Ink4a AP20187 stem cell All-trans Retinoic Acid Promotes Cell Apoptosis
分类号 Q2 [生物学—细胞生物学] R3 [医药卫生—基础医学]
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参考文献47

  • 1Robles S J,Adami G R.Agents that cause DNA double strand breaks lead to p16 INK4a enrichment and the premature senescence of normal fibroblasts.Oncogene,1998,16(9):1113-1123.
  • 2Elmore L W,Rehder C W,Di X,et al.Adriamycin-induced senescence in breast tumor cells involves functional p53and telomere dysfunction.J Biol Chem,2002,277(38):35509-35515.
  • 3Kim J H,Kim J H,Lee G E,et al.Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells.Biochem J,2003,373(Pt2):523-529.
  • 4Michaloglou C,Vredeveld L C,Soengas M S,et al.BRAFE600-associated senescence-like cell cycle arrest of human naevi.Nature,2005,436(7051):720-724.
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  • 6Tong Y,Zhao W,Zhou C,et al.PTTG1attenuates drug-induced cellular senescence.PLoS One,2011,6(8):e23754.
  • 7Baker D J,Wijshake T,Tchkonia T,et al.Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.Nature,2011,479(7372):232-236.
  • 8Von Zglinicki T,Saretzki G,Ladhoff J,et al.Human cell senescence as a DNA damage response.Mech Ageing Dev,2005,126(1):111-117.
  • 9DiLeonardo A,Linke S P,Clarkin K,et al.DNA damage triggers a prolonged p53-dependent G1arrest and long-term induction of Cip1in normal human fibroblasts.Genes Dev,1994,8(21):2540-2551.
  • 10Hasty P,Campisi J,Hoeijmakers J,et al.Aging and genome maintenance:lessons from the mouse?.Science,2003,299(5611):1355-1359.

二级参考文献203

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  • 10Bartkova J, Rezaei N, Liontos M, et al. Oneogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature, 2006, 444(7119): 633 -637.

共引文献23

同被引文献129

引证文献10

二级引证文献47

生物化学与生物物理进展
2012年 第3期

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