摘要
研究了在维生素B1催化下,以无水乙醇为溶剂,1,8-二氨基萘与丁酮反应合成2-乙基-2-甲基-2,3-二氢-1H伯啶的反应,考察了催化剂用量、反应物摩尔比、反应温度、时间等因素对产品收率的影响。结果表明,在电磁搅拌下,当1,8-二氨基萘用量为0.1 mol,丁酮与1,8-二氨基萘的摩尔比在1.2∶1,催化剂用量为2.0%,反应温度为35℃,反应30 min时,最佳产品收率可达到85.2%。维生素B1对该反应具有良好的催化作用,是合成2-乙基-2-甲基-2,3-二氢-1H伯啶的良好催化剂。产品经熔点、红外光谱进行了表征。
Using vitamin B1 as catalyst and ethanol as solvent,2-ethyl-2-methyl-2,3-dihydro-1H-perimidine was prepared from 1,8-naphthalenediamin and butanone.Effects of reaction temperature,time,catalyst dosage and mole ratio of reactants on the yield of 2-ethyl-2-methyl-2,3-dihydro-1H-perimidine were investigated.The optimal conditions were determined as follows： electromagnetic stirring,amount of 1,8-naphthalenediamin 0.1 mol,amount of vitamin B1 2.0%,butanone /1,8-naphthalenediamin molar ratio 1.2︰1,reaction temperature 35 ℃ and reaction time 30 min.The results show that under optimal conditions,the yield of 2-ethyl-2-methyl-2,3-dihydro-1H-perimidine can reach 85.2%,which may confirm that vitamin B1 has good catalytic activity.At last,the product was characterized by melting point and IR.
出处
《当代化工》
CAS
2012年第2期114-115,119,共3页
Contemporary Chemical Industry
