摘要
①目的比较应用草酸铂与+氟脲嘧啶联合肝动脉化疗栓塞术治疗方案与单用静脉滴注草酸铂+氟尿嘧啶治疗方案对结直肠癌术后多发性肝转移癌患者的疗效及副作用。②方法观察组35例应用肝动脉灌注草酸铂+氟尿嘧啶化疗+碘油乳剂栓塞肝动脉。对照组38例静滴草酸铂+氟尿嘧啶。两组均以每4周为1周期,重复4周期后评价疗效。客观疗效与毒性反应按WHO标准进行评价。③结果观察组、对照组客观疗效分别为68.6%及34.2%,中位生存期观察组14.6个月,对照组10.3个月,白细胞减少、周围神经毒性反应两组差异无显著性(P>0.05),恶心、呕吐、腹痛、发热等副作用观察组显著增加(P<0.05)。④结论草酸钠加氟脲嘧啶方案联合肝动脉化疗栓塞术治疗结直肠癌多发性肝转移的治疗效果优于单一静脉用药。
Objective To compare the effect and side effect of 5 -FU ＋ eloxatin combined with TACE in interventional therapy and 5 - FU ＋ eloxatin in ivdrip therapy of colorectal cancer with the liver metastasis after surgical operation. Methods Group A （35cases） 5 -FU ＋ eloxatin was used for infusion chemotherapy and TACE through proper hepatic artery. Group B （38 cases） eloxatin ＋ 5 - FU was used in-ivdrip therapy. Two for four - weeks courses were initiated. WHO standard was used to evaluate objective effect and toxic effect. Results Treatment effect（ CR ＋ PR） is 58.6% in group A and 34.2% in group B（ P 〈 0.05 ）. Median survival was 14.6 months in group A and 10.3 monthsin group B. side effects such as neutropenia,peripheral never toxicity were found in both groups without significant difference（ P 〉 0.05 ）. side effects such as nausea, vomiting, abdominal painand fever were found in grop A more than group B （ P 〈 0.05 ）. Conclusion The regimen of 5 - FU ＋ eloxatin in interventional therapy combined with TACE is superior to 5 - FU ＋ eloxatin in ivdrip therapy of colorectal cancer with liver metastasis.
出处
《河北联合大学学报（医学版）》
2012年第2期155-156,共2页
Journal of North China Coal Medical College
