摘要
目的观察奥沙利铂联合氟尿嘧啶类药物二线治疗晚期胃癌的近期疗效和安全性。方法采用FOLFOX4方案,即奥沙利铂(L-OHP)85mg/m2静脉滴注2h,d1,四氢叶酸钙(CF)200mg/m2静脉滴注2h,d1、d2,注射后立即静脉推注氟尿嘧啶(5-FU)400mg/m2,d1、d2,5-FU600mg/m2持续静滴d1、d2;每二周重复,28天为一周期。或改良XELOX方案,即L-OHP85mg/m2静脉滴注2h,d1、d15,卡培他滨(Cap)1250mg/m2分两次口服d1～d14,28天为一周期。二个周期化疗结束后进行疗效评价。结果入组观察43例,总有效率为30.2%。其中FOLFOX4组有效率为31.6%,中位TTP为6个月;改良XELOX方案组总有效率为29.2%,中位TTP为5个月。两组总有效率和TTP比较差异无显著性。毒副反应主要为外周神经感觉异常,症状可逆。结论奥沙利铂联合氟尿嘧啶类药物二线治疗晚期胃癌疗效较高,毒副反应可耐受。
Objective To evaluate the effects and safety of oxaliplatin plus fluoriouracil as a second line chemotherapy for patients with advanced gastric cancer. Methods FOLFOX4 regimen(oxaliplatin 85 mg/m^2 in 2-hours infusion on d1,leucovorin 200mg/m^2 infusion 2 hours followed by fluoriouracil 400mg/m^2 d1,d2 and fluoriouracil 600mg/m^2 infusion d1, d2,and repeated every 2 weeks.)or modified XELOX regimen (oxaliplatin 85 mg/m^2 in 2-hours infusion on d1,d15,capecitabine 1250mg/m^2/d twice daily from day 1 to 14,and repeated 28 days)were applied. Efficacy was evaluated at 2 cycles(8 weeks).Results Fourty-three patients were evaluable for respones,overall response rate was 30.2 %. There were 19 cases in FOLFOX4 regimen, overall response rate was 31.6 % and median TTP was 6 months ;24 cases in modified XELOX regimen, overall response rate was 29.2 % and median TTP was 5 months. The major toxicity was reversible peripheral sensory neuropathy. Conclusion Oxaliplatin plus fluoriouracil as a second line chemotherapy is a high response regimen for advanced gastric cancer with mile toxicity.
出处
《现代肿瘤医学》
CAS
2005年第3期361-362,共2页
Journal of Modern Oncology
关键词
胃肿瘤
奥沙利铂
卡培他滨
stomach neoplasma
oxaliplatin
capecitable
