摘要
本研究运用Mannich反应,得到了丹参酮ⅡA的16位被酯化氨基酸取代的5个衍生物,结构均经EI-MS、1H及13C NMR确证。经MTT法测定丹参酮ⅡA及其衍生物对HeLa细胞增殖的抑制作用,并计算出IC50。结果表明,5个衍生物的生物活性较丹参酮ⅡA均有所增强;即丹参酮ⅡA在16位进行结构修饰可以增强其对肿瘤细胞抑制活性。
Five derivatives of Tanshinone Ⅱ A were prepared via Mannich reaction with esterified amino acid. Their structures were characterized by spectral data. The antipreliferative activities of Tanshinone Ⅱ A and the derivatives a- gainst HeLa cells were evaluated by M＇IT assay. All the five derivatives showed higher activity than Tanshinone Ⅱ A, which suggested that modification at C-16 of Tanshinone ⅡA could enhance its inhibitory activity on tumor cells.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2012年第3期385-388,共4页
Natural Product Research and Development
基金
天津市应用基础及前沿技术研究计划(10JCYBJC14500)
中国医学科学院放射医学研究所青年探索基金(ST1116)
