摘要
目的:研究生存素(Survivin)在良、恶性胃溃疡中的表达及其相关性与临床意义。方法:选择良性胃溃疡、有癌前期病变的胃溃疡和溃疡型胃癌病理标本,采用免疫组化S-P染色法检测病理组织中survivin的表达,用AB-PAS法检测区分伴有肠化胃溃疡的结肠化生及小肠化生。结果:Survivin在溃疡型胃癌中的阳性表达明显高于良性胃溃疡(P<0.01),在有癌前病变胃溃疡中的表达明显高于无癌前病变的胃溃疡(P<0.01),伴有结肠化生中的表达高于小肠化生(P<0.05),伴有肠化的胃溃疡中的表达高于有不典型增生胃溃疡中的表达(P<0.05),在溃疡型胃癌中的表达与有癌前病变胃溃疡中的表达无明显统计学意义(P>0.1)。结论:对于有癌前期病变的胃溃疡患者,检测胃黏膜survivin表达水平,并动态随访survivin表达水平的变化,可能对胃溃疡的演变和良、恶性胃溃疡的鉴别有一定的临床价值。
Objective To explore the value of the expression of survivin in the identification of benign and maglinant gastric ulcer. Methods The S-P immunohistochemical method was used to detect the expressions of survivin in 150 cases of paraffin-embedded specimens from different gastric ulcer mucosa, including benign gastric ulcer, precancerous gastric ulcer, and ulcerative gastric cancer. AB-PAS method was used to differentiate the colonic and small intestine intestinal metaplasia. Results The positive expression rates of survivin in ulcerative gastric cancer group and precancerous gastric ulcer group were higher than that in benign gastric ulcer group （P 〈 0.01 ）, in colonic intestinal metaplasia was higher than that in small intestine intestinal metaplasia （P 〈 0.05）, and in gastric ulcer with intestinal metaplasia was higher than that in precancerous gastric ulcer （P 〈 0.05）, but there was no significant difference between that in precancerous gastric ulcer and that in ulcerative gastric cancer. Conclusion The detection and monitoring of the expression of survivin in precancerous gastric ulcer may be benefit for the prediction of the development of gastric ulcer, and the differentiation between benign and malignant gastric ulcer.
出处
《实用医学杂志》
CAS
北大核心
2012年第6期923-925,共3页
The Journal of Practical Medicine
关键词
胃溃疡
溃疡型胃癌
癌前病变
SURVIVIN
免疫组化
Benign gastric ulcer
Ulcerative gastric cancer
Precancerous lesion
Survivin
Immunohisto-chemistry
