摘要
目的:探讨代谢综合征(MS)患者血清Apelin水平的变化。方法:69例MS患者和63例正常糖调节(NGR)者,采用酶联免疫吸附法测定空腹血清Apelin含量,同时检测空腹血糖和胰岛素水平,以稳态模型评价胰岛素抵抗指数(HOMA-IR)。结果:MS组血清Apelin水平明显升高,确诊2型糖尿病MS组明显高于糖调节受损的MS组(475.8±37.3vs451.5±54.7)ng/L(P<0.05)和超重/肥胖者(475.8±37.3vs430.3±52.1)ng/L(P<0.01),且均高于NC组。多元逐步回归分析结果示:ln(HOMA-IR)、BMI和TC是血清Apelin独立相关因素(r2分别为0.459、0.494、0.293,均P<0.05)。结论:MS中多种代谢成分异常与血清Apelin升高密切相关,其可能是由于胰岛素抵抗加重所致。
Objective To investigate the changes of the serum apelin level in patients with metabolic syndrome. Methods Fasting plasma glucose （FPG） and insulin would be determined in order to evluate HOMA insulin resistance （HOMA-IR）, The level of fasting serum apelin was detected by ELISA assay. Meanwhile, the height, weight, waist circumference, blood pressure, HbA1C and lipid profile level were also measured. ResultsThe result showed that the level of serum apelin in MS I group was higher obviously in both MS II and overweight/ obesity groups than the control group （P 〈 0.01 ）. Moreover the level of serum apelin of metabolic syndrome with type 2 diabetes mellitus （475.8 ± 37.3）ng/L was higher than the metabolic syndrome with impaired glucose regulation（451.5±54.7）ng/L（P 〈 0.05） and the group of overweight/obesity 430.3± 52.1 ）ng/L（P 〈 0.01 ）. The differences had signifance in statistics. In a multiple step-wise regression analysis, in （HOMA-IR）, BMI and TC were independent factors related to apelin （r2=0.544, r2 = 0.494, r2 = 0.293, all P 〈 0.05）. Conclusion The increased of serum apelin level is closely related to overweight/obesity, diabetes/impaired glucose regulation, hypertension, dyslipidemia and other metabolic abnormalities of metabolic syndrome, which maybe the increased insulin resistance that caused the level of serum apelin increased in the patients with MS group.
出处
《实用医学杂志》
CAS
北大核心
2012年第6期910-912,共3页
The Journal of Practical Medicine
基金
广西壮族自治区卫生厅科研课题(编号:桂卫Z2007080)
