摘要
目的探讨肥胖2型糖尿病患者血清Apelin水平的变化及其意义。方法糖尿病和肥胖患者的空腹血糖和胰岛素水平,计算胰岛素抵抗指数(HOMA-IR);用酶联免疫吸附法测定患者血清Apelin含量。结果肥胖糖尿病患者32例,正常体重糖尿病31例,单纯肥胖患者34例,正常对照组30例,分别测定血清Apelin比正常对照组明显升高(P<0.01)。肥胖糖尿病组血清Apelin水平为(426.3±35.0)pg/ml明显高于正常体重糖尿病组的(376.4±40.8)pg/ml和单纯肥胖组(392.2±31.1)pg/ml,差异有统计学意义(P<0.01)。结论肥胖和胰岛素抵抗相伴时引起血清Apelin升高,高血糖和肥胖并存加重胰岛素抵抗,导致肥胖糖尿病组Apelin进一步升高。
Objective To investigate the change of serum apelin＇s level in type 2 diabetes mellitus of fat patients,and discuss the sense. Methods Firstly,fasting plasma glucose and insulin would be determined in order to evaluate HOMA insulin resistance （HOMA-IR）. Later the level of serum apelin was detected by ELISA assay. Results 32 cases of type 2 diabetes mellitus with obese,31 cases of type 2 diabetes mellitus and 34 cases of obese were detected respectively for serum apelin,the result showed that the level of serum apelin was higher obviously than the control group （P 〈 0. 01 ）. Moreover the level of serum apelin of group type 2 diabetes mellitus with obese was （426. 3 ± 35.0） pg/ml, it was higher than the other groups [ group type 2 diabetes mellitus was （376.4 ± 40. 8 ） pg/ml and group obese was （392. 2 ± 31.1 ） pg/ml ]. The differences had significance in statisties （P 〈0. 01 ）. Conclusion Patients with beth obesity and insulin resistance have a higher serum apelin level. High plasma glucose and obesity enhance insulin resistance and lead to additional increasing of serum apelin in obese type 2 diabetes mellitus.
出处
《广西医学》
CAS
2009年第5期631-632,共2页
Guangxi Medical Journal
基金
广西医疗卫生科学研究基金(桂卫Z2007080)
关键词
肥胖
糖尿病
APELIN
血糖
胰岛素抵抗指数
酶联免疫吸附法
Obesity
Diabetes mellitus
Apelin
Blood glucose
Insulin resistance index
Enzyme linked immunosorbent assay
