摘要
尿毒症患者心血管系统钙化发生早且严重,心瓣膜钙化较常见。心脏瓣膜钙化不仅能造成瓣膜狭窄和(或)关闭不全,同时还可引起心脏传导受损,导致心律失常、心室肥厚、心功能不全,甚至猝死等。研究表明多种因素参与了尿毒症的心瓣膜钙化,如钙磷代谢不平衡、甲状旁腺激素、活性维生素D、炎症、胎球蛋白A等。心瓣膜钙化是钙化促进因素与抑制因素不平衡的结果。本文就近年来国内外研究现状作一综述。
Cardiovascular calcification happens early and seriously in uremia,of which cardiac valve calcification is relatively common.It can cause not only valve stenosis and（or） incompetence but also arrhythmia,ventricular hypertrophy,cardiac insufficiency,even sudden death,etc.Researches show that many factors were involved in cardiac valve calcification in uremia,such as calcium phosphate metabolism imbalance,parathyroid hormone,vitamin D,inflammation,fetuin-A,etc.Cardiac valve calcification is the imbalance of the results of calcification promoters and inhibition.Its mechnism in recent years is reviewed in this paper.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2012年第3期283-288,共6页
Chinese Journal of Arteriosclerosis
关键词
尿毒症
心瓣膜
钙化
钙磷代谢
甲状旁腺激素
胎球蛋白A
Uremia
Cardiac Valve
Calcification
Calcium Phosphate Metabolism
Parathyroid Hormone
Fetuin-A
