摘要
目的分析2型糖尿病肾衰竭继发性甲状旁腺功能亢进的相关因素。方法选取该院收治的110例2型糖尿病肾衰竭患者作为研究对象,所有患者均经过影像学检测以及实验室诊断为2型糖尿病肾衰竭,病情稳定且未进行甲状旁腺手术治疗,分析其临床资料以及相关实验室指标,比较不同甲状旁腺激素(PTH)水平的患者临床表现及实验室检测差异,采用单因素及多因素分析方法探讨影响2型糖尿病肾衰竭继发性甲状旁腺功能亢进患者的危险因素。结果 110例患者根据甲状旁腺激素水平将其分为低PTH组61例(PTH<300pg/mL)及高PTH组49例(PTH≥300pg/mL),根据患者的一般资料并采用单因素分析发现,高血压、年龄、肌酐、脉压、透析时间、三酰甘油和C-反应蛋白、血磷水平是影响继发性甲状旁腺功能亢进的危险因素;多因素分析发现,高血压、透析时间、C-反应蛋白和血磷水平升高则是对SHPT造成影响的独立危险因素,其中高血压与SHPT呈负相关。结论高血压、透析时间、C-反应蛋白和血磷水平升高是诱发甲状旁腺功能亢进的独立危险因素,对继发性甲状旁腺功能亢进进行早期诊治能够有效延缓慢性肾衰竭的进行性发展。
Objective To analyze the related factors of secondary hyperparathyroidism（SHPT）in type 2diabetes mellitus（T2DM）patients with renal failure.Methods One hundred and ten T2 DM patients with renal failure treated in our hospital were selected as the study subjects.All cases were diagnosed as renal failure by the imaging examination and laboratory detections.The disease condition was stable without the parathyroid operation treatment.Their clinical data and related laboratory indicators were analyzed.The differences in clinical manifestations and laboratory detection were compared among the patients with different parathyroid hormone（PTH）levels.The univariate and multivariate analysis method was adopted to analyze the risk factors affecting T2 DM renal failure patients with SHPT.Results One hundred and ten patients were divided into the low PTH group（61cases,PTH〈300pg/mL）and high PTH group（49cases,PTH≥300pg/mL）according to PTH level;according to the patient＇s general data,adopting the single factor analysis found that hypertension,age,creatinine level,pulse pressure,dialysis duration,triglyceride,C-reactive protein and serum phosphorus level arise were the risk factors of secondary hyperparathyroidism,in which hypertension was negatively correlated with SHPT.Conclusion Hypertension,dialysis duration,C-reactive protein and serum phosphorus level are the independent risk factors inducing SHPT.Early diagnosis and treatment of SHPT can effectively delay the progressive development of chronic renal failure.
出处
《检验医学与临床》
CAS
2017年第6期805-807,共3页
Laboratory Medicine and Clinic
关键词
糖尿病
甲状旁腺功能亢进
血磷
血钙
diabetes mellitus
hyperparathyroidism
blood phosphorus
blood calcium
