摘要
目的 观察超声引导下微波凝固治疗肝癌前后患者Ｔ细胞亚群的动态变化。方法分别于治疗前１ 周及治疗完成后１ ，２ ，３ ，４ 周采集患者外周静脉血，用流式细胞仪检测Ｔ 淋巴细胞及亚群。结果 肝癌患者存在严重的免疫功能低下，与正常人比ＣＤ３、ＣＤ４ 、ＣＤ４／ＣＤ８ 下降，ＣＤ８ 上升。微波凝固治疗肝癌后，ＣＤ４／ＣＤ８ 比值明显升高，疗后３ 周由１ ．０９ ±０．２３ 达１．３８ ±０ ．３６ ，热疗后免疫功能明显改善的患者肝癌复发率低，无明显改善者复发率高。结论 微波热疗后肝癌患者免疫功能增强，免疫指标的变化与疗效可能有着密切关系。
Objective To study the dynamic change of T-lymphocyte subsets in liver cancer patients treated with ultrasound(US)-guided percutaneous microwave coagulation.Methods The peripheral blood T-cell subsets were evaluated using flow cytometry.The blood samples were collected before treatment and 1,2,3,4 weeks after treatment.Results It showed that the immune function of liver cancer patients was lower obviously;CD3,CD4 and CD4/CD8 reduced as well as CD8 raised.After microwave treatmentof 20 patients,the ratio of CD4/CD8 in 12 cases was markedly increased.While other 8 cases were not obviously changed.Moreover,the rate of tumor relapse in patients having immune function improvement was lower than that of those with no immune amelioration.Conclusion The results suggest that microwave therapy can enhance the immune function of liver cancer patients,the immunologic indexes are closely related to manifestation of curative effect.So the microwave coagulation therapy is playing an important role for anti-tumor effect.
出处
《中华理疗杂志》
2000年第1期15-17,共3页
Chinese Journal of Physical Therapy
关键词
肝癌
微波治疗
超声引导
T细胞亚群
Microwaves
Carcinoma,Hepalocellular
T-lymphocyte subsets
