摘要
目的探讨非小细胞肺癌（NSCLC）患者血清中骨桥蛋白（OPN）水平及其临床意义。方法采用酶联免疫吸附法（ELISA）测定102例NSCLC患者和42例良性肺部疾病患者血清OPN水平，选取同期本院门诊健康体检30例正常人血清作为对照组，分析OPN与肺癌临床特征及预后的关系。结果NSCLC患者血清OPN水平明显高于良性肺部疾病患者和健康对照组（P〈0．01）。不同性别、年龄、病理类型和病理分级NSCLC患者之间血清OPN水平接近，差异均无统计学意义（P〉0．05）。Ⅲ-IV期的患者血清OPN水平高于Ⅰ-Ⅱ期患者；有淋巴结转移患者高于无淋巴结转移的患者；手术前患者高于手术后患者；复发后患者明显高于复发前患者；存活期3年以上患者明显低于存活期3年以内患者，各组差异均有统计学意义（P〈0．01）。结论血清OPN水平能够反映疾病的严重程度，其指标对判定手术效果、监测复发和评估预后等具有指导意义。
Objective To explore the levels and clinical significance of osteopontin （OPN） in ser- um of patients with non-small cell lung cancer （NSCLC）. Methods OPN levels of 102 cases of NSCLC, 42 cases of benign lung disease and 30 cases of healthy control were measured by enzyme-linked immunosor- bent assay（ELISA）. Results The serum OPN levels of NSCLC were significantly higher than those of be-nign lung disease group and healthy control group （ P 〈 0.01 ）. The levels of OPN in serum were compared between different gender, age, histological differentiation and pathological type groups, but there were no significant difference （ P 〉 0. 05）. The serum OPN levels of Ⅲ - stage NSCLC patients, with lymph node metastasis, before operation patients, recrudescent patients, survival below 3 years patients were rela-tively higher than that in the patients withⅠ - Ⅱ stage, without lymph node metastasis, after operation, no recrudescent, survival over 3 years patients, and the differences were significant （ P 〈 0. 01 ）. Conclu- sions OPN levels in serum reflected the severity of the disease, which can be used to determine the effects of surgery and monitor recurrence and evaluate prognosis.
出处
《中国医师杂志》
CAS
2012年第2期179-181,共3页
Journal of Chinese Physician
