摘要
目的检测Twist蛋白在前列腺癌组织中的表达，探讨其在前列腺癌发生发展中的作用、与临床病理特征及预后的关系。方法应用免疫组织化学（Enlivion^TM）法分别检测Twist蛋白在70例前列腺癌、30例癌旁组织中的表达情况。结果（1）Twist蛋白在前列腺癌的表达高于癌旁组织，差异有统计学意义[61．4％（43／70）VS13．3％（4／30），X^2=19．50，P〈0．01]；Twist表达与前列腺癌的Gleason分级、临床分期、骨转移及组织坏死有关（P〈0．05），与年龄无关（P〉0．05）；（2）Twist蛋白附性患者生存率明显低于阴性患者，其差异有统计学意义（X^2=9．52，P〈0．01）。结论Twist可能是前列腺恶性转变以及前列腺癌浸润转移的重要生物学标志，其高表达预示肿瘤侵袭性高及预后不良。
Objective To investigate the expression of Twist protein in adenocarcinoma of prostate and clinicopathological features and explore its roles in the carcinogenesis and progression of adenocarcinoma of prostate and its relationship with prognosis. Methods The expression of Twist was detected in 70 cases with adenocarcinoma of prostate and 30 cases with side cancer tissue by immunohistochemistry （Enlivi- onTM ）. Results The expression of＇Twist protein in adenocarcinoma of prostate was higher than side cancertissue. The expression of twist was related to Gleason grade, clinical stage and bony metastasis （ P 〈 0.05 ）, but it was not related to the age （ P 〉 0. 05 ）. The survival rate of Twist protein positive patients was significant lower than negative patients （ X^2 = 9. 52, P 〈 0.01 ）. Conclusions Twist might be an im- portant biological marker for malignant transformation and invasion and metastasis adenocarcinoma of pros- tate, and the up-regulation of the expression of Twist reflects more invasion and poor prognosis.
出处
《中国医师杂志》
CAS
2012年第2期170-172,共3页
Journal of Chinese Physician
