摘要
羊水中存在多能性干细胞,它们不仅阳性表达胚胎干细胞(embryonic stem cell,ESC)表面标志物,如SSEA-4,保持未分化状态的转录因子OCT-4,胚胎多能性维持因子Nanog等;而且阳性表达成人干细胞(adult stem cell,ASC)表面标志物CD29和CD44等,在特定的诱导条件下能够分化为代表三胚层生殖层系。
Human amniotic fluid contains pluripotent stem cells, which positively express markers of embryonic stem cells, like SSEA-4, Oct-4 and Nanog; and also markers of adult stem ceils, like CD29 and CD44. Under specific inducing conditions, they are capable of differentiating into lineages representing three embryonic germ layers.
出处
《同济大学学报（医学版）》
CAS
2012年第1期113-116,共4页
Journal of Tongji University(Medical Science)
基金
上海市自然科学基金(10ZR1423500)
上海市卫生局科研项目(2008008)
关键词
羊水
多能性干细胞
培养
分化
amniotic fluid
pluripotent stem cells
culture
differentiation
