摘要
浆料粘度是热诱导相分离法制备支架材料的关键因素,采用不同粘度的纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合浆料制备了相应的n-HA/PA66多孔支架,并对不同粘度浆料制备支架材料的泡孔结构和力学性能等进行了对比研究。结果表明,浆料粘度对n-HA/PA66复合多孔支架的孔径、孔径分布、孔隙率、开孔率、力学强度等性能有显著的影响。随着浆料粘度的增大,制备支架的孔径、孔隙率、开孔率逐渐减小,而力学强度却逐渐增大。当浆料粘度为330Pa.s时,制备出的n-HA/PA66复合多孔支架综合性能最好,其孔径主要分布在200～500μm,平均孔径(324±67.1)μm,孔隙率为(75±1.6)%,开孔率为(59±2.5)%,抗压强度为(2.12±0.90)MPa,能够较好地满足骨组织工程支架材料对孔径、孔隙率和力学性能的要求。
The viscosity of slurry plays an important role in fabrication of porous scaffolds by using thermally induced phase separation method. In this paper, nano-hydroxyapatite/polyamide 66 （n-HA/PA66） porous scaffolds were prepared with n-HA/PA66 composite slurry of different viscosity to investigate the influence of slurry viscosity on structure and mechanical property of the fabricated scaffolds. The pore structure and mechanical property of the scaffolds were compared. The results show that the pore size, pore distribution, total porosity and interconnective porosity of n-HA/PA66 scaffolds reduce with the increase of slurry viscosity, while mechanical property of the scaffolds change in an inverse tendency. When the slurry viscosity is 330Pa · s, the aperture is mainly distributed in the 200-500 micron, the n-HA/PA66 porous scaffold exhibite an appropriate average pore size of （324±67.1）μm, porosity of （75±1.6）% and interconnective porosity of （59±2.5）%, as well as compressive strength of （2.12±0.90）MPa, which will be desirable for bone tissue engineering.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2012年第6期798-802,共5页
Journal of Functional Materials
基金
国家自然科学基金青年科学基金资助项目(51002099)
国家高技术研究发展计划(863计划)资助项目(2011AA030103)
关键词
浆料粘度
纳米羟基磷灰石/聚酰胺66
泡孔结构
力学性能
slurry viscosity
nano-hydroxyapatite/polymide66 scaffold
porousstructure
mechanical property
