摘要
目的观察沙美特罗-氟替卡松复合吸入剂联合沙丁胺醇雾化吸人治疗急性加重期慢性阻塞性肺疾病的临床疗效。方法60例慢性阻塞性肺疾病急性加重期患者随机分为观察组和对照组各30例，对照组采用常规治疗的基础上加用沙丁胺醇氧气驱动雾化吸入治疗，观察组在对照组治疗的基础上加用沙美特罗-氟替卡松复合吸入剂雾化吸入治疗，比较两组临床疗效。结果观察组显效18例、好转10例、无效2例、总有效率93．3％；对照组显效9例、好转11例、无效10例、总有效率66．7％。两组总有效率差异有统计学意义（x^2=4．60，P〈0．05）。治疗后观察组一秒用力肺活量（FEV1）、功能肺活量（FVC）较治疗前、对照组治疗后均明显改善（t=2．629、2．649、2．064、2．051，均P〈0．05）。结论沙美特罗一氟替卡松干粉复合吸入剂联合沙丁胺醇氧气驱动雾化吸入治疗慢性阻塞性肺疾病急性加重期疗效优于单用沙丁胺醇。
Objective To observe the clinical efficacy of fluticasone salmeterol inhaler combined with salbutamol inhalation of oxygen-driven treatment of chronic obstructive pulmonary disease with acute exacerbation. Methods 60 patients of chronic obstructive pulmonary disease with acute exacerbation ,randomly divided into observation and control groups of 30 patients each. The control group on the basis of conventional treatment with salmeterol plus flutica sone inhalation powder compound and the oxygen-driven albuterol inhalation aerosol liquid, the other group by conventional therapy based on the use of oxygen-driven albuterol inhalation aerosol solution, then compare the clinical curative effects. Results There were 18 examples excellencely, i0 examples improve, 2 examples ineffective of observation group with total effective rate 93.3% ;9 examples excellencely, 11 examples improve, 10 examples ineffective of control group with total effective rate 66.7%. The contrast of total effective power with the two groups exists the staffstical significance （ X2 = 4.60,P 〈 0.05 ） o In the observation group, FEV1 and FVC of post-treatment, were better than pretherapy and post-treatment of control group （ t = 2. 629,2. 649,2.064,2.051, P 〈 0. 05 ）. Conclusion Salmeterol and fluticasone propionate inhalation powder hybrid atomizing inhalation of salbutamol effective than salbutamol alone.
出处
《中国基层医药》
CAS
2012年第4期483-484,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺疾病
慢性阻塞性
投药
吸入
沙美特罗
氟替卡松
沙丁胺醇
Pulmonary disease, chronic obstructive
Administration, inhalation
Salmeterol, fluticasone
Salbutamol
