摘要
目的比较新辅助化疗方案紫杉醇（PTX）联合氟尿嘧啶（5-Fu）／甲酰四氢叶酸钙（LV）（PF方案）和奥沙利铂（L-OHP）联合5-Fu／LV（FOLFOX方案）用于进展期胃癌综合治疗的近期疗效。方法60例临床确诊的进展期胃癌（Ⅲ-Ⅳ期）患者随机分为PF组和FOLFOX组，每组各30例，分别采用PF和FOLFOX方案进行新辅助化疗3周期，比较两种化疗方案对进展期胃癌的近期疗效和不良反应。结果PF组化疗后总有效率77．67％，FOLFOX组总有效率50．00％，两组差异有统计学意义（x^2=4．59，P〈0．05）；两组白细胞减少、转氨酶升高及恶心和腹泻程度相似；PF组脱发程度较重，但两组差异无统计学意义（P〉0．05）；FOL-FOX组末梢神经感觉异常明显，两组差异有统计学意义（x^2=5．08，P〈0．05）。结论PF化疗方案近期疗效显著，耐受性好。
Objective To observe the recent effects and toxicity in advanced gastric carcinoma by two kinds of neoadjuvant chemotherapies （ PF and FOLFOX）. Methods A total of 60 patients with advanced gastric cancer （Ⅲ-Ⅳ ） , they were randomly divided into 2 groups ; PF group （ 30 cases） and FOLFOX group （ 30 cases）. All patients were given 3 cycles of docetaxel or L-OHP chemotherapy preoperatively, to observe the recent effects and toxicity in advanced gastric carcinoma. Results The total effective rate in PF group was 77.67 %, while it was 50.00% in FOLFOX group,it had significant difference between in two groups （ x^2 = 4.59, P 〈 0.05 ）. There is no difference in the incidence of neutropenia, transaminase elevation, nausea and diarrhea two groups. The incidence of hair loss in PF group is higher than in FOLFOX group, but there is no difference between two groups;The incidence of peripheral nerve paresthesia in FOLFOX group is higher than that in PF group （ x^2 = 5.08, P 〈 0.05）. Conclusion PF as neo- adjuvant chemotherapy is a very effective and well-tolerated regimen in patients with advanced gastric cancer.
出处
《中国基层医药》
CAS
2012年第3期337-338,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胃肿瘤
抗肿瘤联合化疗方案
紫杉醇
奥沙利铂
Stomach neoplasms
Antineoplastic combined chemotherapy protocols
Docetaxel
Oxaliplatin
