摘要
目的:比较番泻叶超微饮片与不同粉体的体外溶出特性。方法:采用桨法进行体外溶出试验,高效液相色谱法测定番泻叶超微饮片与不同粉体不同时间点番泻苷A和番泻苷B的溶出量,计算累积溶出百分率,并对其进行威布尔分布函数拟合。结果:番泻叶中粉、细粉、超微粉与超微饮片之间的溶出速度具有明显差异,超微饮片中番泻苷A和番泻苷B的溶出量最大,累积溶出70%的时间明显小于其他粉体。结论:番泻叶超微饮片具有快速溶出、高效溶出有效成分的特点。
OBJECTIVE： To compare the dissolution property of Cassia angustifolia ultramicro decoction pieces and different powders in vitro. METHODS： Paddle method was used to determine the dissolution of effective constituents. HPLC method was developed for the dissolution amount of sennoside A and sennoside B in the different periods. We calculated the accumulative dissolu- tion rate, and fitted the fimction of Weibull distribution. RESULTS： There was a obvious difference in dissolution among C. angus- afolia plain powder, fine powder, ultramicro powder and ultramicro decoction piece. Especially, the large amount of sennoside A and sermoside B dissolved from ultramicro decoction piece, and the value of T07 was significantly lower than that of others. CON- CLUSION： C. angustifolia ultramicro decoction pieces has the characteristics of fastest and most efficient dissolution.
出处
《中国药房》
CAS
CSCD
2012年第11期989-991,共3页
China Pharmacy
基金
国家中医药管理局中医药行业科研专项项目(200807054)
关键词
番泻叶
超微饮片
溶出度
高效液相色谱法
威布尔模型
Cassia angustifolia
Ultramicro decoction pieces
Dissolution
HPLC
Weibull＇s mode
