摘要
目的:探讨同步放化疗治疗局部晚期食管癌的疗效及不良反应。方法:根据入选标准随机将49例局部晚期食管癌患者分为单纯放疗组(单放组)24例和放疗+化疗组(放化组)25例。2组均采用60CO或6MV-X线放射治疗,食管癌原发灶剂量单放组为60～68 Gy,30～34分次,6.0～6.5周;放化组为54～60 Gy,27～30分次,5.5～6.0周,区域淋巴结剂量50～60Gy,25～30分次,5.0～6.0周。放化组从放疗第1天起给予氟尿嘧啶500 mg/m2静脉滴注5 d,顺铂20 mg/m2静脉滴注4 d。结果:放化组与单放组治疗有效率分别为92.00%和79.17%,差异无统计学意义(P>0.05)。放化组和单放组的1、2年生存率分别为68.00%、32.00%和58.33%、20.80%,差异均无统计学意义(P>0.05)。放化组和单放组的1、2年局控率分别为72.00%、36.00%和66.67%、25.00%,差异均无统计学意义(P>0.05)。放化组不良反应较单放组略有增加,但多数患者均能耐受。结论:放疗联合顺铂、氟尿嘧啶治疗局部晚期食管癌的近期疗效和局控率相对较好,有提高生存率可能,虽不良反应增加但多数患者可以耐受。
Objective： To evaluate the effectiveness and toxicity of concurrent chemoradiotherapy on locally advanced esophageal carcinoma. Methods：Forty-nine cases with locally advanced esophageal carcinoma were randomized into the first group （24 cases） treated only with radiotherapy and the second group （25 cases） treated with chemoradiotherapy combined cisplatin （20 mg/m2 day 1 -4 ） and 5-fluorouracil （500 mg/m2 day 1 -5 ）. All cases were irradiated with60 CO or 6MV-X ray. The radiation dose of the first group was 60 - 68 Gy in tumor for 30 - 34 times and sustained 6.0 - 6.5 weeks. The radiation dose of the second group was 54 - 60 Gy in tumor for 27 - 30 times and sustained 5.5 - 6.0 weeks, and 50 - 60 Gy, 25 - 30 times and sustaining 5.0 - 6.0 weeks for regional lymph nodes. The second group were injected droply with 5-fluorouracil（500 mg/m2） for 5 days and cisplatin（20 mg/m2） for 4 days. Results：The effective rates of chemoradiotherapy group and radiotherapy group were 92.00% and 79.17 %, respectively, the difference of the effective rates had no statistically significance （ P 〉 0.05 ）. The 1-year, 2-year overall survival rate （OS） and locoregional progression-free survival（LPFS） of chemoradiotherapy group and radiotherapy group were 68.00% ,32.00% and 58.33% ,20.80% , and 72.00% ,36.00% and 66.62% ,25.00% ,respectively. The LPFS and OS had no statistically significant difference between the two groups（P 〉0.05 ）. The toxicity of chemoradiotherapy group was heavier than the radiotherapy group, hut the most patiens were tolerable. Conclusions： The chemoradiotherapy combined cisplatin and 5-fluorouracil can enhance the survival rate of patiens with locally advanced esophageal carcinoma and the adverse response is tolerable.
出处
《蚌埠医学院学报》
CAS
2012年第2期153-156,共4页
Journal of Bengbu Medical College
基金
蚌埠医学院自然科学研究资助项目(BY1038)
