摘要
目的观察纳洛酮治疗老年慢性肺源性心脏病合并肺性脑病的治疗效果。方法将入选80例病例随机分为治疗组及对照组各40例,对两组患者给予抗感染、持续氧流量为1～3L/min,低流量吸氧(给氧浓度为25%～35%),解痉平喘、止咳化痰、保持呼吸道通畅、维持酸碱、水电解质平衡、营养支持等综合治疗。治疗组在此基础上加用纳络酮注射液(0.4 mg/支),首剂负荷量0.8mg,加入5%葡萄糖20ml中静脉推注,连用3d。结果治疗组总有效率为85%,对照组总有效率为60%,两组疗效比较差异有统计学意义(P<0.05);治疗组pH值、PaO2、PaCO2均优于对照组,差异有统计学意义(P<0.01或P<0.05)。结论纳络酮治疗肺性脑病能降低PaCO2,提高PaO2和PH值。缩短患者的清醒时间,无明显不良反应,值得在临床上推广应用。
Objective To observe the effect of naloxone in treatment of chronic pulmonary heart disease complicated pulmonary encephalopathy.Methods The selected 80 cases were randomly divided into treatment group and control group of 40 patients,two groups are to be anti-infection,continuous low flow oxygen（oxygen concentration of 25% to 35%,oxygen flow rate of 1~3L/min,nasal oxygen catheter method,spasm and asthma,cough and phlegm,keep the airway open by maintaining acid,water and electrolyte balance,nutritional support,comprehensive treatment in the treatment group based on the use of naloxone injection（0.4 mg / branch）,the first dose load 0.8mg,20ml of 5% glucose intravenous injection,once every 3d.Results The total effective rate of treatment group was 85%,in the control group the total effective rate was 60%,compared two groups the difference was significant;Treatment group the pH,PaO2,PaCO2 than the control group,the difference was significant（P0.01 or P0.05）.Conclusions Naloxone in treatment of pulmonary encephalopathy significantly reduce PaCO2 improve PaO2 and PH value,shorten the patient＇s awake with no apparent side effects,it is widely promoted in clinical practice.
出处
《医药论坛杂志》
2011年第24期80-81,共2页
Journal of Medical Forum
关键词
纳洛酮
肺心病
肺性脑病
Naloxone
Pulmonary
Encephalopathy
