摘要
目的探讨异种脱细胞真皮基质(ADM)在难愈性创面修复中的应用价值。方法选取新疆维吾尔自治区人民医院烧伤、创面修复外科2005年6月至2011年6月收住的各种难愈性创面患者84例,按随机数字表法分为试验组41例和对照组43例。两组常规清创后,试验组创面使用ADM覆盖,对照组常规应用生理盐水、凡士林纱布覆盖,每例患者选取4cm×4cm大小创面作为观察区域,比较两组治疗后1d、3d、7d、12d肉芽组织生长情况及临床治疗时间。结果异种脱细胞真皮基质移植术后第5天两组创面肉芽组织生长开始有区别,治疗后7d,试验组肉芽创面(24.87±0.24)%与B组(18.66±0.45)%相比差异有统计学意义(P<0.01);试验组创面愈合时间为(16.17±1.87)d,较B组(32.71±3.95)d明显缩短,差异有高度统计学意义(P<0.01)。结论异种脱细胞真皮基质作为创面覆盖物,能有效地保护创面,促进创面血管化形成,缩短临床治疗周期。
Objective To discuss the effect of cover allogeneic skin on severe damaged wound, accelerate wound bed preparation and wound’s healing. Methods Eighty-four emergency patients were selected who had severe damaged wound in skin and soft tissues during June 2005 to June 2011. According to the different treatments, the patients were divided into two groups. The former had 41 cases using allogeneic skin cover as treatment group and the latter had 43 cases using first stage skin grafting as control group. The success rate and healing rate of this two treatments were observed. Results After two regular debridement, group A were covered with acellular dermis matrix （ADM）, group B were covered with the Saline gauze and the Vaseline oil sands. Every 4 cm × 4 cm size of the wound of each patient was selected as a viewing area. The growth of granulation tissue and clinical treatment time of two groups were compared after treated 1 d, 3 d, 7 d, 12 d. Results After treatment of 7 d, granulation wounds of group A （24.87±0.24） were significantly different compared with group B （18.66±0.45）. The time of wound healing in group A was （16.17 ± 1.87） d, which was significantly shorter than group B （32.71±3.95） d, and the difference was highly statistically significant （P 0.01）. Conclusion As a wound cover allogeneic skin, it can effectively protect the wound and promote wound vascularization and shorten the clinical treatment cycle.
出处
《中华损伤与修复杂志（电子版）》
CAS
2011年第6期18-20,24,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
新疆维吾尔自治区人民医院课题基金项目(20100110)
关键词
生物敷料
伤口愈合
难愈性创面
Biological dressings
Wound healing
Severe damaged wounds
