摘要
目的 为研究 TGF- α与卵巢癌发生发展的关系。方法 采用免疫组化、原位杂交方法检测了 TGF- α在 72例卵巢肿瘤及正常卵巢组织中的表达。结果 TGF- α和其m RNA在卵巢癌中的阳性率为 71.0 5 %和 5 7.89% ,在良性肿瘤、交界性肿瘤和正常卵巢组织中的检出率分别为30 .0 0 %和 2 0 .0 0 %、5 8.33%和 33.33%及 41.6 7%和16 .6 7% ,各组与卵巢癌组间均有显著差异 (P<0 .0 5 )。EGF在上述各类组织中极少表达。表明 TGF- α在卵巢肿瘤中有高水平的表达 ,且恶性程度越高 ,表达率越高。结论 TGF- α的自分泌在卵巢癌的发生发展中起着重要的作用 ,而
Objective To study the expression of TGF α and EGF in ovarian neoplasm and to discuss the relationship between these factors and the development and occurrence of ovarian cancer.Methods Immunohistochemistry and in situ hyhridization were used. Results The positive rate of TGF α protein and mRNA in ovarian cancer, benign tumor, borderline tumor and normal ovarian tissue were 71.05 % and 57.89 %, 30.00 % and 20.00 %, 58.33 % and 33.3 %, 41.67 % and 16.67 % respectively. There was significant difference between ovarian cancer group and other groups ( P <0 05). Very low positive rates of EGF were detected in these tissues. Conclusion TGF α autocrine mechanism plays an important role in the occurrence and development of ovarian cancer, but EGF doesn't.
出处
《肿瘤》
CAS
CSCD
北大核心
2000年第2期118-120,共3页
Tumor
关键词
卵巢肿瘤
表皮生长因子
免疫组织化学
原位杂交
Ovarian neoplasm
Transforming growth factor-α
Epidermal growth factor
Immunohistochemistry
In situ hybridization
